Prophylactic Effect of Clofibrate on Hyperbilirubinemia in Very Low Birth Weight Twins
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 7
Abstract
Aims: To determine the prophylactic effects of clofibrate on hyperbilirubinemia in very low birth weight twins. Study Design: A randomized double blind clinical trial Place and Duration of Study: Department of Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, between Oct 2010- Sep 2011. Methodology: Forty neonates with very low birth weight (20 pairs of twins) having same blood group and sex were elected. Infants with congenital anomalies, metabolic diseases, hemolytic disease, and infections were excluded. Case group received a single dose of clofibrate 100 mg/kg and control group received sterile water. Both clofibrate and sterile water were administrated through orogastric tube and were the same volume. Serum bilirubin levels were measured before administration, 24, 48, 72 and 96 hours after the administration. Data was analyzed using repeated measure ANOVA. Results: Total serum bilirubin after clofibrate administration was lower than control group (F= 6.48, P=0.02); however, the duration of phototherapy and hospitalization were not significantly different between the two groups (P=0.39 and 0.91 respectively). No side effects of drug were observed based on the physical exam and liver function tests. Conclusion: These findings suggest that clofibrate maintained total serum bilirubin lower in very low birth weight neonates but without effect on duration of phototherapy and hospitalization.
Authors and Affiliations
Mohammadzadeh Ashraf, Farhat Ahmadshah, Esmaeli Habibullah, Javanrouh Niloofar
Phytochemical Screening and Antibacterial Activity of Five Malaysian Medicinal Plants
Natural drugs play important and vital role in the modern medicine. It is usually used to cure some ailments which may not be treated by conventional medicine. Natural drugs may exhibit many biological activities, such a...
Anti-inflammatory Activity of Cucumis sativus L.
Aims: To evaluate the anti-inflammatory activity and acute toxicity of Cucumis sativus L. Study Design: Animal model assays of anti-inflammatory. Place and Duration of Study: Department of Biochemistry, University of Ni...
Synthesis of Selenium Nanoparticles by Bacillus laterosporus Using Gamma Radiation
Aim: This study shows the possible synthesis of Selenium Nanoparticles (SeNPs) in aerobic optimized conditions using Bacillus laterosporus (B. laterosporus) bacterial strain. Methodology: B. laterosporus was used to redu...
A New Emulsifying Agent: Cucumis sativus Linnaeus Mucilage
Aim: This study aims at investigating the emulsifying properties of Cucumis sativus mucilage, compare with gelatin and tragacanth with further assessment of their combined effects on the emulsion properties. Place and D...
Effects of Oxidation on Protein-Nanoparticle Interactions
Aims: Upon entrance into the blood stream most nanoparticles bind to an array of proteins forming a “protein corona”. Fibrinogen is the second most abundant blood protein and has been reported to bind to a variety of nan...