Prophylactic Gabapentin for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Context: Prevention and treatment of postoperative nausea and vomiting continues to be a major challenge in postoperative care. Gabapentin is an antiepileptic drug .Its antiepileptic action is demonstrated in chemotherapy-induced acute and delayed onset of nausea and vomiting in breast cancer patient. Aims: The aim of this study was to evaluate the antiemetic effect of gabapentin on incidence and severity of postoperative nausea and vomiting in laparoscopic surgery. Methods and Material: Sixty adult patients of ASA grade I & II scheduled for laparoscopic surgeries like lap appendicectomy, lap cholecystectomy, lap hernia repair were randomly assigned into two equal groups to receive 600 mg gabapentin (Group G, n=30) or matching placebo (Group P, n= 30) two hours prior to surgery. Conventional anaesthesia technique was applied to every patient. Ondansetron 4mg was used intravenously as rescue medication for emesis. Statistical analysis used: Incidence and severity of postoperative nausea and vomiting (PONV) were compared between the study groups in the next 12 hours. Results: Demographic data and the duration of anaesthesia were not significantly different between the two study groups .Six patients in group G had PONV in 12 hours compared with 18 patients in group P (P<0.05). Eighteen patients (60%) in group G had no incidence of PONV in comparison with twelve patients (40%) in group P (P<0.05). Conclusions: Administration of oral gabapentin before laparoscopic surgery effectively suppresses nausea and vomiting.
Authors and Affiliations
Dr Sourabh Roy, Dr Krishna Gupta
Keywords
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- EP ID EP590335
- DOI 10.9790/0853-1601090913
- Views 67
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