PROPHYLACTIC USE OF EPHEDRINE TO ATTENUATE THE HAEMODYNAMIC RESPONSES TO PROPOFOL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2016, Vol 3, Issue 14
Abstract
BACKGROUND The beginning of anaesthesia since October 16th 1846. THE ETHER DAY Inhalational methods had dominated the practice of Anaesthesia. The most important factor in the increasing popularity of intravenous anaesthesia has been the availability of PROPOFOL since 1980s. Over a period of time it has become the drug of choice for induction. But, the hypotension induced by Propofol has been a matter of concern. AIM OF STUDY To study the prophylactic use of ephedrine to attenuate the haemodynamic responses to propofol. MATERIALS AND METHODS Sixty patients belonging to ASA grade I and II belonging to either sex were included in the study. They were aged between 20-50 years. These patients were randomly divided into two groups. Group I included patients who received 2mg/kg Propofol as induction dose and group II received 20mg ephedrine 2 min before induction with 2mg/kg Propofol. RESULTS Fall in blood pressure was found in both the groups but, the fall was statistically insignificant in Group II who received ephedrine. CONCLUSION The prophylactic use of ephedrine significantly attenuated the decrease in blood pressure associated with induction of anaesthesia with propofol.
Authors and Affiliations
Mahesh M, Sanjeev Rao A
Keywords
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- EP ID EP232692
- DOI 10.18410/jebmh/2016/108
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