Prophylactic Use of Ondansetron for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2018, Vol 6, Issue 3
Abstract
The prophylactic antiemetic efficacy of intravenous ondansetron was evaluated in a prospective randomized, double blind comparison with the placebo in 80 patients undergoing laparoscopic cholecystectomy under general anaesthesia. Patients were randomly allocated to receive ondansetron 8mg (4 ml) or placebo (Normal saline, 4m1) before induction of a standardised general anaesthesia. The incidence of nausea was 60% in placebo and 35% in the ondansetron group (p <0.01). Similarly the incidence of vomiting was 22.5% in the placebo group and 5%' in the ondansetron group (p <0.01). Finally, only 32.5% of the ondansetron treated patients required a rescue antiemetic compared with 57.5% in the placebo group. Thus, in patients undergoing laparoscopic cholecystectomy ondansetron (8mg) before induction of anaesthesia appears to be a promising antiemetic for the prevention of PONV.
Authors and Affiliations
Harbhupinder Singh, Gurlivleen Kaur, Surinder Singh, Dhanwant Kaur
Keywords
Related Articles
- EP ID EP532665
- DOI -
- Views 115
- Downloads 0
The Developmental Motor Outcomes of Infants with Hypoxic Ischaemic Encephalopathy II and III between the Ages of 12-14 Months at Rural Medical College, Loni, Maharashtra
Background: This study determined outcomes for motor developmental delay in infants, 12-14 months, diagnosed with HIE II and III, at Rural Medical College at Loni, Maharashtra during year 2009 July to 2012 January. Mater...
ASSESSMENT OF RISK FACTORS ASSOCIATED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A CLINICAL STUDY
Background: Chronic obstructive pulmonary disease (COPD) is a major cause of disability and death all over the world. In India, it is recognized as a major health problem requiring management from the primary health car...
A Study on the Use of Gingival Crevicular Blood for Measuring Glucose to Screen for Diabetes and Comparison of Measurements of Glycated Hemoglobin in Periodontitis Cases and Gingivitis Subjects
Aim- Diabetes mellitus and chronic periodontitis are the most common chronic diseases in the adult world population. Many people suffering from diabetes around the globe do not know that they have diabetes. A dental / pe...
Evaluation of Soft Tissue Changes in Patients using Twin block appliance pre- post treatment comparison
Background: Functional appliance therapy is a commonly used treatment protocol for growing Class II patients. There appears to be a consensus that removable functional appliance therapy leads to improvement on facial app...
TREATMENT OF ALTERED PASSIVE ERUPTION RELATED GUMMY SMILE- A CASE REPORT
Background: This report describes the management of a case with gummy smile by esthetic crown lengthening, along with gingival depigmentation using 980 nm diode laser. Methods: A 23 year old male patient reported with th...