Prophylaxis of oxidative stress and correction of antioxidant protection of poultry poisoned by "Neoverm"
Journal Title: Біологія тварин - Year 2016, Vol 18, Issue 1
Abstract
The data on the effect of a new antihelminthic preparation "Neoverm" (a derivative of avermectins) on hens have been presented in the article. The preparation was administered at a single toxic dose. It has been found out that as a result of the production of a higher level of POL products in the blood of the fowl there was not enough potential of the fowl’s own resources of AOS to prevent the influence of AMO and the corresponding inclusion of protective antiradical mechanisms but the above process can be corrected with the help of the preparation "E-selen" at 5-fold dose. The mechanism of proоxidant action of "Neoverm" at a toxic dose (0.4 cm3/kg body weight) was to form the surplus of toxic products of lipid peroxidation — DC and MDA (on average by 2,5 and 2,2 times (P≤0,05), respectively, as compared to the values of the above indices in the control hens) — when the fowl’s own antioxidant resources were lost because of the inhibition of catalase activity and the reduction of the level of structural antioxidants — vitamin E, selen and catalase activity (by 1.9, 0.23 (P≤0,05) and 2.3 times (P≤0,01), respectively) that demonstrates the formation of oxidative stress in the experimental hens. One can assert the expressed antioxidant effect of the preparation "E-selen" by the results of the restoration of the pool of endogenic antioxidant resources (intensification of catalase activity by 1.9 times (P≤0,01) as compared to the fowl that received only "Neoverm", the normalization of the general AOA to physiological level, increase in the concentration of structural components of non-fermentative part of AOS — vitamin E and selen by 6.1 and 1.3 times (P≤0,001), respectively) in the blood of hens.
Authors and Affiliations
Yu. Svitlychna-Kulak
Keywords
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