Prospective observational study of cutaneous adverse drug reactions at a tertiary medical college
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 9, Issue 2
Abstract
Background: Adverse cutaneous drug reactions (ADR) are considered as one among the leading cause of mortality and morbidity. They cause 3-6% of hospital admissions at any age and up to 24% in elderly population. This study was done to analyze clinical pattern of ADR, mortality and morbidity of patients with ADRs. Materials And Methods: This study was a prospective observational study conducted at Department of DVL, Santhiram medical college and general hospital , Nandyal from August 2017- DECEMBER 2018 . All the patients who attended DVL OPD and those who are admitted in the wards with suspected ADR were included in the study. The patient’s data was recorded in a prestructured proforma that includes detailed clinical history, general and cutaneous examination. Assessment of severity of adverse reaction was done using HARTWINGS severity assessment scale. Results: Total 101 were reported from AUGUST 2017- DECEMBER 2018. Maximum ADRs were reported in the age group of 31-40 (33.6%). Females were affected more than males. Mild ADRs were found in 44, moderate in 44 while severe ADRs were noted in 13. Patients reported with Fixed drug eruption – 50 ( 49.5%),Drug induced acne form eruptions - 16 ( 15.8%) , Maculopapular rash -7 ( 6.93 % ) , Steven – Johnson syndrome – 5 ( 4.95%) , Erythema multiforme – 5 ( 4.95%) , Drug induced erythema nodosum - 5 ( 4.95%) , Toxic epidermo necrolysis -4 ( 3.95%) , Drug induced urticaria – 3 ( 2.9%) ,Drug induced pemphigus vulgaris – 2( 1.9%) , Drug induced Exfoliative dermatitis - 2 ( 1.9 % ) , Dapsone syndrome – 2 ( 1.9%) . The major drug group which was implicated in cutaneous adverse drug reactions was NSAIDs with frequency of 50.5%.
Authors and Affiliations
Preetham Pottipati, N Sai Pujitha, Madhavilatha Midde, Praveena Thiriveedhi
Keywords
Related Articles
- EP ID EP516440
- DOI 10.26611/10219213
- Views 64
- Downloads 0
Profile of patients suffering from dengue: A cross sectional study
Background: India is one of the seven identified countries in the South-East Asia region regularly reporting incidence of DF and Dengue Hemorrhagic Fever outbreaks and may soon transform into a major niche for dengue inf...
Study of correlation between dyslipidemia and cerebrovascular accidents in non-diabetic patients at tertiary health care center
Background: According to the Indian Council of Medical Research there were 930,985 cases of stroke in 2004 in India. Aims and Objectives: to Study correlation between dyslipidemia and cerebrovascular accidents in non-dia...
Clinical profile and etiology of craniocerebral trauma patients
Background: Traumatic brain injury has a high mortality and morbidity especially in developing nations. Head injury following trauma is the cause of death in about one-third of patients that die after accidents. Objectiv...
Venous Doppler and 2D Echocardiography findings in pulmonary embolism cases
Background: Pulmonary thromboembolic disease refers to the condition in which blood clot(s) (thrombus or multiple thrombi) migrate from the systemic circulation to the pulmonary vasculature. Amis and objective: To study...
Metabolic syndrome in HIV/AIDS in Manipur
Background: Metabolic syndrome is a complex disorder considered as a worldwide epidemic. A variety of endocrine and metabolic disorders are seen in the context of HIV infection which may be direct consequence of HIV infe...