PROSPECTIVE, OPEN, NON-RANDOMISED COMPARATIVE STUDY TO ASSESS EFFICACY OF 0.5% TIMOLOL MALEATE EYE DROP WITH COMBINATION TREATMENT OF 2% DORZOLAMIDE AND 0.5% TIMOLOL MALEATE EYE DROPS IN PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 73
Abstract
BACKGROUND Glaucoma is among the leading causes of blindness in the developing world and a major health problem in the developed world. The goal of glaucoma treatment is to preserve good visual function for patient’s lifetime. This is accomplished by lowering the IOP to a level that will stop or at least slow the progression of optic nerve damage and its consequent visual field loss. This study is a prospective, open, non-randomised comparative study to assess efficacy of 0.5% Timolol maleate eye drop with combination treatment of 2% Dorzolamide and 0.5% Timolol maleate eye drops in patients with primary open angle glaucoma. MATERIALS AND METHODS 60 patients were enrolled after informed and written consent as per inclusion and exclusion criteria. Current medical and ophthalmic history and diagnosis were noted during the first visit. Patients were assigned to receive Timolol or the combination of Dorzolamide and Timolol using a 1:1 allocation. Thereafter, patients were advised to self-instil one drop of timolol twice daily or one drop of the combination twice daily according to the group they had been allotted to. After enrolment into the study followup was done after 2 weeks, 4 weeks and 6 weeks. To avoid the effect of diurnal variation, it was taken care to note the IOP between 11 a.m. - 1 p.m. The primary efficacy endpoint was the change from baseline of intraocular tension. Statistical tests were used to analyse data that were paired ‘t’ test and unpaired ‘t’ test. RESULTS The mean age of patients of timolol group was 53.96 ± 5.23 years and that of dorzolamide + timolol was 53.46 ± 5.28 years. In all two Timolol and Dorzolamide + Timolol groups, 50% patients were males and 50% patients were females. Number of cases subjected to statistical analysis were 27 in timolol group and 28 in Dorzolamide + timolol group. The mean baseline intraocular pressure in timolol group was 25.27 ± 1.22 mmHg, while in Dorzolamide + timolol group was 25.50 ± 1.28 mmHg. Values of mean reduction in IOP were compared between Dorzolamide + timolol with timolol. It was found to be statistically significant (p < 0.05) at 2 weeks and highly significant (0.001) at 6 weeks. CONCLUSION When efficacy of fixed combination of timolol and Dorzolamide was compared with timolol drugs used, we found that combination of timolol and Dorzolamide was more effective in reducing IOP as compared to the individual drugs used alone.
Authors and Affiliations
Sathish C Shitole, Deshmukh S. S
Keywords
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- EP ID EP265839
- DOI 10.14260/Jemds/2017/1139
- Views 65
- Downloads 0
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