Prospective randomised study comparing concomitant chemo-radiotherapy using three weekly Cisplatin and biweekly 5- Fluoro-uracil versus weekly Paclitaxel in patients of locally advanced carcinoma cervix
Journal Title: MedPulse -International Medical Journal - Year 2018, Vol 5, Issue 4
Abstract
India being the second most populous country in world, accounted for 25% of cervical cancer death according to GOLOBOCAN 2012. Although there are many agents available, the need for a model chemotherapy regimen which is effective and at the same time less toxic and has easy affordability is the current unmet need. We devised a study with the most commonly available and affordable drugs like Cisplatin, 5Fluoro-uracil and Paclitaxel. The main objective was to study the efficacy of concurrent chemo-radiotherapy in treatment of carcinoma cervix using two different regimens in terms of clinical response evidenced clinically as well as on imaging. Secondary objectives were to assess the progression free survival and overall survival. It was clearly evident that the response rate could be appreciated clinically in arm B over arm A, however this difference could not be justified by statistical methods. The toxicities observed in both the arms was comparable and in terms of progression free survival and overall survival the differences were not significant suggesting that the both the options could be considered in the treatment. Although the outcome looks promising prompting xploration of more such combination which are easily available in the rural hospitals, but due to smaller sample size and smaller follow up, a multi-institutional study with a larger sample size and a longer follow-up is definitely required to set the ball rolling in favor of combination chemotherapy including cisplatin and 5FU.
Authors and Affiliations
Sapna Marcus, Jasmeet Kaur, Hanuman Yadav, Seema Grover, Paramveer Singh, Rahul Chowdhary, Pardeep Garg, Raja Paramjeet Singh
Keywords
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