Prospective Randomized Study on the Effectiveness of Oral Antibiotic Prophylaxis in Preventing Surgical Site Infection in Elective Colorectal Surgery
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Background: Surgeries of the colon and rectum are categorized as clean-contaminated procedures. Increased incidence of surgical site infections associated with these procedures make antibiotic prophylaxis and bowel preparation an essential component in the preoperative preparation of the patients. While the role of intravenous antibiotics is well established, controversy still exists over the use of oral antibiotics for prophylaxis. This study was undertaken to evaluate the role of oral antibiotic prophylaxis in preventing/ reducing the incidence of wound infection following elective colorectal surgeries. Methods: 82 patients who underwent elective surgeries on the colon/rectum over 32 months were included in the study. They were randomized into two groups – Group 1 (with oral prophylaxis) and Group 2 (without oral prophylaxis). Postoperatively intravenous antibiotics were given for 2 days following which no antibiotics were given. Wound was inspected for evidence of infection. Results: Overall incisional SSI rate was 31%. Infection rate was higher in females (33.3%) than in males (30%). Patients with higher ASA grade had high infection rates (p<0.0001) (Grade I – 14.3%; Grade II – 26%; Grade III – 50%). Patients in age group > 60 yrs had increased infection rates (p<0.0001) (20 – 40 yrs – 14.3%; 40 – 60 yrs – 26.1%; > 60 yrs – 50%). 5 patients from Group 1(n=40) and 8 from Group 2 (n=42) developed incisional SSI without any statistically significant difference (p=0.514). One patient developed urinary tract infection. Conclusion: This study did not find any significant role for oral antibiotics in decreasing the infection rates. Hence oral antibiotics need not be administered preoperatively for colorectal surgeries.
Authors and Affiliations
Govindappa Saroja Murali
Keywords
Related Articles
- EP ID EP214072
- DOI -
- Views 92
- Downloads 0
Abruptio placenta: A Retrospective Study on Aetiological Factors and Maternal Outcomes
Background: Abruptio placenta denotes separation of a normally implanted placenta after 20 weeks of gestation. This is a uniquely dangerous condition to both the mother and the foetus because of its potentially serious p...
Feasibility of Weekly Cisplatin Versus Gemcitabine Concomitant with Radiation in The Management of Locally Advanced Carcinoma Cervix
Introduction: Cervical cancer is the fourth most common malignancy in women worldwide (1). The study was conducted to evaluate the feasibility, toxicity and response of weekly gemcitabine against the widely accepted week...
Takayasu Arteritis and PRES Syndrome - A Rare Case Series
PRES is a very rare manifestation of Takayasu’s arteritis. It can present with headache, seizures, altered sensorium with visual disturbances. Two young teenager patients presented in ward with complaints of severe heada...
Prevalence of Gestational Diabetes Mellitus among Cohort of Pregnant Women Registered in Primary Health Center
Background: Gestational Diabetes Mellitus (GDM) is an important public health problem in India. The prevalence of GDM is constantly on the rise, globally. Women with GDM are at increased risk for adverse obstetric and pe...
Prevalance of Dental Caries among School Children of Hajipur Village A Rural Area of Katihar, Bihar
This study was conduct in Rural Health Training Centre, Hajipur of Katihar Medical College, Katihar. Four hundred children were selected from four schools randomly. Children were examined by two dentists. The presence of...