PROSPECTIVE STUDY ON COMPARISON OF INTRAOPERATIVE FROZEN SECTION AND CYTOLOGICAL TECHNIQUES AS DIAGNOSTIC MODALITIES OF OVARIAN MASS LESIONS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 42
Abstract
BACKGROUND Frozen section and cytology in gynaecological pathology have received less attention till date. This research focusses on indications and limitations of per-operative diagnostic techniques in pathology. Ovarian neoplasms are heterogeneous group of benign and malignant tumours classified on different cells of origin. Histopathology, however, remains the gold standard in tissue diagnosis. MATERIALS AND METHODS A descriptive study was conducted including 31 cases. Frozen section was performed on tissue specimens received in normal saline on thermo scientific HM525 cryostat. Simultaneous scrape and imprint smears were prepared and all slides stained with H and E, Giemsa and read by two independent pathologists. Results were then compared with histopathology of each case. RESULTS Frozen section in ovarian lesions showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy values of 85.7%, 100%, 100%, 87.5% and 92.9% respectively. Aspirate cytology showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy values of 40%, 100%, 100%, 62.5% and 70% respectively. Imprint cytology showed sensitivity, specificity, positive predictive value, negative predictive value and accuracy values of 33.3%, 100%, 100%, 60% and 66.7%. CONCLUSION Comparison of intraoperative histology and cytology show that though cytology provides supporting information preoperatively, frozen section examination is more reliable in deciding extent of surgery in ovarian mass lesions.
Authors and Affiliations
Sonal Dwivedi, Riddhi Jaiswal, Nisha Singh, Ajay Kr Singh, Madhumati Goel
Keywords
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- EP ID EP214157
- DOI 10.14260/Jemds/2017/725
- Views 69
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