Prospects of application of bismuth drugs in the treatment of H. pylori-associated gastric ulcer in the case of patients undergoing cytostatic therapy
Journal Title: Медицинский альманах - Year 2016, Vol 1, Issue 1
Abstract
The aim of the study was to determine the efficacy of the bismuth drugs in patients with gastric ulcer, receiving cytotoxic therapy.Peptic ulcer, in patients receiving combination chemotherapy, dyspeptic syndrome is characterized by severe, advanced stage and a relatively low degree of chronic gastritis and H. pylori contamination of the gastric mucosa. In patients receiving combination chemotherapy is determined by a significant level of violation of regeneration in the form of atrophy, intestinal metaplasia, dysplasia of the gastric mucosa associated with serious violations of cell homeostasis, under the control of regulatory molecules PCNA, Bcl-2, NF-kB and tachykinins (substance P, neurokinin A). In the subgroup of patients receiving regimens as part of peptic ulcer drugs bismuth less determined violations of the chair (p <0.05) were verified lower rates of expression of factor NF-kB (p<0.05). The rate of healing of ulcers in the subgroup of patients receiving the therapy as part of bismuth preparations did not differ significantly (р˃0.05)occasionally scarring ulcers in the subgroup of those treated without drugs bismuth.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP206515
- DOI -
- Views 99
- Downloads 0
Pathogenetic mechanisms of respiratory disfunctions in the case of bronchial asthma of children
Children who are sick with asthma respiratory disorders were accompanied by a decrease in bronchial obstruction, irregular zone of ventilation, hyperairiness of lung, oppression of mucociliary clearance, which implementa...
Peculiarities of organizing medical assistance to patients having obstructive diseases of pancreas in Komi Republic
The efficiency of 3 level medical care system is shown. The level of hospital is determined by the diagnostic possibilities and human resources. The task of I level is the diagnosis of biliary and duodenal obstruction of...
Energy deficiency condition – basis of hypotrophy and comorbid pathology in the case of children
Research objective – at children of the first year of life to define pathogenetic metabolism links, significant for development of a hypotrophy, with prospect of correction of the revealed violations. 52 children with de...
Peculiarities of diagnostic aid materials in the case of patients having diabetic foot syndrome from the point of view of epidemiological safety
Compliance with preventive measures when determining the degree of nutrition of lower extremity tissue segments in the case of patients having diabetic foot syndrome shall be regarded within a comprehensive approach – ep...
Comparative analysis of microorganisms separated from the patients in resuscitation departments of a different profile
The research represents materials of studying etiological structure of microorganisms separated from pathologic loci of patients in Resuscitation and Intensive Care Departments of different specialization. Frequency of c...