Prostasomas: search of biomarkers for the early detection of prostate cancer
Journal Title: TecnoLógicas - Year 2019, Vol 22, Issue 44
Abstract
Prostate cancer is the second most diagnosed disease in men worldwide, with an increasing mortality rate in recent years. Currently, there are two early detection tests, the measurement of blood levels of prostate-specific antigen and digital rectal examination of the prostate. However, these tests do not present optimal specificity and sensitivity for their detection. Although different studies have looked for new biomarkers by means of the implementation of technologies, such as new generation sequencing, mass spectrometry, among others, the same disadvantages persist, therefore, they have not allowed their use in clinical practice; The discovery of new biomarkers for the diagnosis of prostate cancer is a challenge for the scientific community. Prostasomes correspond to extracellular vesicles secreted by normal prostate or tumor tissue that can be detected in different fluids. Structurally, prostasomes differ from other exosomes, by their size, membrane composition and specific protein content, which makes them a potential and novel source of clinical biomarkers. In this context, this review presents an overview of protein biomarkers, isolated from prostasomes present in different biological fluids, for the possible diagnosis of prostate cancer. For this, a systematic PubMed search was carried out for studies in proteomics for prostate cancer, with criteria such as extracellular vesicles, exosomes and prostasomes, as well as blood, urine, seminal fluid, among other biological samples.
Authors and Affiliations
Manuela Antonia García, Julieth Rueda, Johanna Pedroza-Díaz
Keywords
Related Articles
- EP ID EP549722
- DOI 10.22430/22565337.1181
- Views 103
- Downloads 0
Development and Evaluation of an Interactive System for the visually impaired
This document presents the experimentation, development and results of testing conducted on a computer application designed for visually impaired people. The interactive system aims to promote some plac...
Collaborative work as a didactic strategy for teaching/learning programming: a systematic literature review
The incorporation of Collaborative Work into programming courses has been identified as a potential strategy that could maximize student participation and have a positive impact on learning. In the...
Numerical and experimental validation with bifurcation diagrams for a controlled DC–DC converter with quasi-sliding control
This paper presents a stability analysis of a buck converter usinga Zero Average Dynamics (ZAD) controller and Fixed-Point Induction Control (FPIC) when the control parameter 푁, the reference vo...
Homogeneous and heterogeneous catalysts of Fe3+, Co2+ and Cu2+ for the degradation of methyl parathion in diluted aqueous medium
Degradation of pesticides (plaguicides, herbicides, fungicides, among others) in aqueous media is a subject of great importance for ensuring the water quality into numerous hydric sources. This work reports the assessmen...
Optimal management of vegetation maintenance and the associated costs of its implementation in overhead power distribution systems
Network operators work constantly to maintain an appropriate level of reliability in their power supply and to preserve the integrity of the vegetation growing underneath overhead power distribution systems. Accordingly,...