Prostate Specific Antigen: A Diagnostic Marker in Polycystic Ovarian Syndrome
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 1
Abstract
ABSTRACT Introduction: Polycystic Ovarian Syndrome (PCOS) is a common condition affecting females in the reproductive age group. Its diagnosis rests on clinical features like obesity, hirsutism, irregular menstrual flow, polycystic ovarian morphology on ultrasonography and laboratory investigations like serum estimation of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), prolactin, dehydroepiandrosterone. The Prostate Specific Antigen (PSA) has been found to be raised in hyperandrogenic states and therefore can be used as a marker for diagnosis of PCOS. Aim: The study was undertaken to evaluate serum PSA levels in patients of PCOS and its possible use in diagnosis of PCOS. Materials and Methods: The case-control study included 40 women with PCOS and 40 age matched healthy women as controls. Serum PSA, LH, FSH and Prolactin levels were measured using immunometric technique. The data so obtained was statistically analysed using Student's t-test. Pearson correlation was used to test the correlation between LH, FSH, Prolactin and total PSA (tPSA). Results: Mean value of serum PSA was significantly higher in women with PCOS (0.03 ng/mL) as compared to control group (0.01 ng/mL). Serum PSA level of >0.01 ng/mL showed 100% sensitivity and specificity. Serum PSA levels had a positive correlation with serum LH levels (p-value 0.001) and serum prolactin levels (p-value 0.03). However, no correlation between PSA and FSH (p-value 0.042) was observed. LH/FSH ratio was raised in 32 out of 40 cases and reversed in remaining eight cases. Conclusion: The serum PSA level with cut-off value >0.01 ng/mL can be used to detect hyperandrogenism in women and therefore can be used as a diagnostic marker for diagnosis of PCOS.
Authors and Affiliations
Kiran Bhat, Meena Bhandari, Vaishali Garg
Keywords
Related Articles
- EP ID EP555089
- DOI 10.7860/JCDR/2019/38177.12500
- Views 83
- Downloads 0
Does Individual Deprivation Affect the Sense of Coherence and Oral Health Status of Individuals?
ABSTRACT Introduction: Studies using deprivation status indicators are scarce in the field of oral health research. Deprivation indicators are poverty indicators that help to understand how poverty affects the health sta...
Role of Shear Wave Elastography in Diagnosis of Benign and Malignant Thyroid Nodules
ABSTRACT Introduction: The role of Virtual Touch Imaging Quantification (VTIQ), a non-invasive Shear Wave Elastography (SWE) mechanism for analysing Thyroid Nodule (TN) elasticity, in differentiating benign from malignan...
The Constitutional Balanced Translocation t(11;22)(q23;q11.2)-An Indian Account
ABSTRACT Introduction: The balanced translocation t(11;22) is one of the most common constitutional genetic abnormality detected in humans. Carriers of the t(11;22) are usually phenotypically normal and their carrier sta...
Anterior Space Maintainer Incorporating a Pontic Derived from a Strip Crown
Various designs of functional and aesthetic space maintainers have been used in the anterior region to replace missing upper primary anteriors. All of these had utilised pontics made of composite, acrylic or natural teet...
Modelling the Health Economic Impact of Influenza Vaccination Strategies for High-Risk Children in Vietnam
ABSTRACT Introduction: In Vietnam, since 2011 a National Influenza Surveillance System in Vietnam has implemented Severe Acute Respiratory Infection (SARI) surveillance to assemble information and inform administrational...