Protective association of IKAP T3214A polymorphism with asthma in a North Indian population: a case-control study
Journal Title: Bioresearch Communications - Year 2016, Vol 2, Issue 1
Abstract
IKAP participates in activation of NF-κB and activated NF-κB is associated with over production of various inflammatory cytokines, chemokines and eotaxin genes in asthma. Genotyping of IκB kinase complex associated protein (IKAP) G2295A, T3214A and C3473T polymorphisms were carried out in a total of 964 individuals (483 healthy controls and 481 asthma patients) from a North Indian population using the PCR-RFLP method. Statistical analysis revealed a significant protection from asthma in TA genotype (OR=0.75, p=0.046) and combination of TA+TT genotype (OR=0.76, p=0.043) of T3214A polymorphism. Some asthma phenotypes were also found to be protective with this polymorphism. However, no polymorphism was observed in G2295A and non-significant association was found for C3473T polymorphism. Haplotype analysis of T3214A and C3473T polymorphisms found TA and TT to be significantly associated with asthma (p=0.016 and 0.012). The present study concludes that T3214A polymorphism confers protection from asthma among the studied North Indian population.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP484553
- DOI -
- Views 196
- Downloads 0
Effect of PTPRδ rs17584499 C/T Polymorphism on Therapeutic Efficacy of Metformin in Bangladeshi Patients with Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) is a polygenic and complex disorder that is difficult to treat effectively in the long term without oral anti-diabetic agents. Genetic variants of these susceptible genes provided the new...
Antioxidants and Total Phenolics of Ludwigia repens rubin Partially Improve the Hepatic Damage Induced by Carbon Tetra Chloride in Animal Model
This research investigated the antioxidative and hepatoprotective properties of Ludwigia repens methanol extract. Antioxidative effects were measured by DPPH radical scavenging method and FeCl3 reducing power assay metho...
Early Excision Burn Wound With Guidance of Methylene Blue
Burn management is serious problem regarding mortality, morbidity and cost. It is a headache to surgeons to manage wound specially major burn wound. It is also expensive due to prolonged hospital stay and needs lot of me...
In vitro Erythrocyte Membrane Stabilization Properties of Solanum aethiopicum L. Fruit Extracts
This study aims at evaluating the membrane stabilization potential of Solanum aethiopicum L. fruits extracts using an in vitro hemolytic assay. 2 mL of blood from healthy volunteers and patients with serologically confir...
In vitro Efficacy of Plant Extracts on Seed Germination and Fungal Infection of Six Varieties of Wheat (Triticum aestivum L.)
The fungitoxicity of six plants extract viz., Allium sativum L., Azadirachta indica A. Juss., Citrus limon (L.) Burm. f., Datura metel L., Gynura procumbens Merr. and Thuja occidentalis L. were evaluated on seed germinat...