Protective effect of Andrographis paniculata on hyperglycemic mediated oxidative damage in renal tissues of diabetic rats
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 6
Abstract
The aim of this study is to evaluate the protective effect of ethanol extract of Andrographis paniculata (A. paniculata) on hyperglycemic mediated oxidative damage in the renal tissues of experimental diabetic rats and to determine the potential bioactive components of A. paniculata ethanol extract was scrutinized using GC-MS techniques. Diabetes was induced in rats by streptozotocin. Experimental period, the animal body weight, blood glucose, urea, serum proteins, cholesterol, antioxidant key enzymes and histological changes in kidneys were determined. The untreated diabetic and A. paniculata treated diabetic groups lost weight and consumed less quantity of food compared to the normal group. We noted decrease in blood glucose in the ethanol extract of A. paniculata treated diabetic group compared to normal and glibenclamide treated groups. The serum protein level was increase and cholesterol and urea levels were significantly (P<0.01) reduced in the A. paniculata extract treated group compared to the normal group. The levels of lipid peroxides in Plasma and kidney tissues were found to be elevated and kidney tissue enzymes of Superoxide dismutase, Catalase and Glutathione peroxidase were found to be decreased in streptozotocin induced diabetic rats when compared to normal. After treatment of A. paniculata, it brings back to significantly (P<0.01) near normal levels. Diabetes associated with marked histological changes in the kidney over a period of 32 days as revealed by tubular epithelial hypertrophy, glomerulosclerosis and glycogen accumulation. Treatment with A. paniculata extract afforded significant protection from renal damage whereas tubular damage was more pronounced in rats treated with glibenclamide. According to traditional indigenous medicinal systems of India this plant has got several medicinal effects without producing any severe side effects. This plant could be very well used as prevention of hyperglycemic complications and tissues damaging through the oxidation.
Authors and Affiliations
V. Sivakumar, S. Rajeshkumar
Keywords
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