Protective Effect of BCG Against The Development of Severe Pulmonary Tuberculosis
Journal Title: IJSR-International Journal Of Scientific Research - Year 2016, Vol 5, Issue 8
Abstract
Tuberculosis is a major public health problem. Parenchymal components like cavities are predominant in post primary tuberculosis. The course and prognosis of a cavitary and extensive disease differs from that with non-cavitary and minimal disease. Morbidity and mortality figures are high in extensive disease. Much controversy exists on the efficacy of BCG vaccination in preventing Tuberculosis. BCG vaccinated persons have lesser chances of getting disseminated and other severe forms of tuberculosis. This is a Case control study to identify the strength of association between BCG vaccination and severity of pulmonary tuberculosis. There were 80 cases and 80 controls. Cases were patients with severe disease and controls were patients with minimal disease.,Severity of tuberculosis was assessed by chest radiographic criteria as per American Thoracic Society recommendation. The study was done over a period of 18 months. Both inclusion and exclusion criteria were applied in the selection of cases and controls. 31.25% of controls and 2.5% of cases shoed BCG scar. Univariate and Multivariate analysis were done. The results showed that BCG had significant protective effect against the development of severe pulmonary tuberculosis and this was independent of age.
Authors and Affiliations
BALACHANDRAN J, MATHEW NINAN
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