Protective effect of Cardiospermum halicacabum on potassium dichromate induced nephrotoxicity in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 4
Abstract
Potassium dichromate is a chemical compound widely used in metallurgy, chrome plating, chemical industry, textile manufacture, wood preservation, photography, photoengraving, refractory, stainless steel industries and cooling systems. Potassium dichromate a compound is the most toxic form of cr (VI) and has been demonstrated to induce nephrotoxicity associated with oxidative stress in humans and animals. Aim The present study was aimed to investigate the protective effect of Cardiospermum halicacabum against potassium dichromate induced nephrotoxicity in rats. Materials and Methods Rats were divided into four groups of 6 animals each. Group III & group IV received methanolic extract of Cardiospermum halicacabum (100mg/kg, 200mg/kg b.w respectively) consecutively for 5 days. Group 1 (control) received normal saline only. Group II (toxic) received vehicle for 5 days. A single dose of K2cr2o7 (20mg/kg) was administered subcutaneously on 4th day to all the animals except group 1. The protective effects of Cardiospermum halicacabum on K2cr2o7 induced nephrotoxicity was investigated by assaying oxidative stress biomarkers, lipid peroxidation, kidney toxicity markers and by histopathological examination of kidney. Results and Conclusion Cardiospermum halicacabum pretreatment prevented toxic effects induced by K2cr2o7 through a protective mechanism that involved reduction of oxidative stress as well as by restoration of histopathological change against K2cr2o7 administration. In conclusion, the results of the present study showed that the methanolic extract of Cardiospermum halicacabum has protective effect against potassium dichromate induced nephrotoxicity.
Authors and Affiliations
K. Somasekhar Reddy
Keywords
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