PROTECTIVE EFFECT OF COX INHIBITORS ON LIPOPOLYSACCHARIDE INDUCED SICKNESS BEHAVIOUR OR NEUROINFLAMMATION AND OXIDATIVE STRESS ON MALE WISTAR RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 6
Abstract
Objectives: The aim of the study was to evaluate the protective effect of COX inhibitors on lipopolysaccharide induced sickness behaviour or neuro inflammation and oxidative stress on male wistar rats.Methods: Male albino wistar rats were divided into 8 groups and each group consisting of 6 rats and drug treatment has done for one week. Control group was given normal saline daily by i. p route for 7 days. Negative control group receives saline for 6 days followed by LPS on 7th day. All other group receives Resveratrol, Celecoxib, and Aspirin for 7 days and LPS (inducing agent) was given on 7th day just before half an hour of drug treatment. After 2 hours of drug administration, the animals were subjected to behavioural testing and after analyzing behavioural parameters, the animals were sacrificed by cervical dislocation in order to perform in vitro studies.Results: The results of this study showed that Celecoxib at 10 and 50 mg/kg p. o. showed no changes in body weight but there is the decrease in the temperature, increase in the locomotor activity, increase in the number of line crossing, head dipping/nose poaking, decrease in the floating time when compared to the negative control group. Resveratrol at 50 and 100 mg/kg p. o. showed a significant increase in the Superoxide Dismutase, Catalase, Glutathione Reductase, and showed significant decrease in the Lipid Peroxide and Nitric Oxide level when compared to the negative control group.Conclusion: It was finally concluded that Celecoxib showed neuro protective activity and Resveratrol showed anti-oxidant property. Â
Authors and Affiliations
Jayashree V, Prakash R
Keywords
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