Protective effect of curcumin and picroliv on chronic alcoholic liver cirrhosis of rat induced with low caloric diet
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 11
Abstract
The present investigation aims at evaluation of the protective efficacy of picroliv and curcumin alone and combination against chronic ethanol exposure induced liver damage. Alcoholic liver cirrhosis was induced in the rat by low calorie diet feeding along with oral ethanol intake in gradually increasing concentration (25-75%) over the duration of 35 days (5 weeks). Picroliv (30 mg/kg) and curcumin (70 mg/kg) were given orally 2 h after the ethanol administration starting from the fifth week, continuously for seven days. On 35th day animals were sacrificed, blood and organ samples were collected, and SGOT, SGPT, ALP, cholesterol (TC), triglyceride (TG), bilirubin, total protein, and albumin were measured. Curcumin alone and in combination with picroliv showed a reversal of body weight loss induced by alcohol. Picroliv, curcumin, and the combination of picroliv and curcumin significantly (P < 0.001) reduced SGOT, SGPT, ALP, TC, and TG. Histopathology of liver section showed mostly normal hepatocytes with the absence of necrosis and cirrhosis in the combination treated group. Picroliv and curcumin combination significantly reduced hyperlipidemia, hyperbilirubinemia, replenish albumin loss, reversed cirrhosis, necrosis and inflammatory changes in the liver may be due to free radical scavenging, antioxidant and membrane stabilizing properties suppressing alcohol induced expression of cytokines and chemokines.
Authors and Affiliations
Papiya Bigoniya, Alok K. Shukla, Wasi-ur Rahman
Keywords
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