Protective effect of D-ribose against inhibition of rats testes function at excessive exercise
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2011, Vol 7, Issue 3
Abstract
An increasing number of research studies point to participation in endurance exercise training as having significant detrimental effects upon reproductive hormonal profiles in men. The means used for prevention and correction of fatigue are ineffective for sexual function recovery and have contraindications and numerous side effects. The search for substances effectively restoring body functions after overtraining and at the same time sparing the reproductive function, which have no contraindications precluding their long and frequent use, is an important trend of studies. One of the candidate substances is ribose used for correction of fatigue in athletes engaged in some sports. We studied the role of ribose deficit in metabolism of the testes under conditions of excessive exercise and the potentialities of ribose use for restoration of the endocrine function of these organs. 45 male Wistar rats weighing 240±20 g were used in this study. Animals were divided into 3 groups (n=15): control; excessive exercise; excessive exercise and received ribose treatment. Plasma concentrations of lactic, β-hydroxybutyric, uric acids, luteinizing hormone, total and free testosterone were measured by biochemical and ELISA methods. The superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase activities and uric acids, malondialdehyde, glutathione, ascorbic acids, testosterone levels were estimated in the testes sample. Acute disorders of purine metabolism develop in rat testes under conditions of excessive exercise. These disorders are characterized by enhanced catabolism and reduced reutilization of purine mononucleotides and activation of oxidative stress against the background of reduced activities of the pentose phosphate pathway and antioxidant system. Administration of D-ribose to rats subjected to excessive exercise improves purine reutilization, stimulates the pentose phosphate pathway work, inhibits oxidative stress of the testes, and saves the testicular endocrine function.
Authors and Affiliations
E Chigrinskiy , V Conway
Keywords
Related Articles
- EP ID EP160711
- DOI -
- Views 108
- Downloads 0
Response of Two Tomato Cultivars to Field-applied Proline and Salt Stress
An experiment was carried out using saline water (6.57 dS.m[sup]-1[/sup]) and subsurface drip irrigation (SDI) on two tomato cultivars ([i]Solanum lycopersicum[/i], cv. Rio Grande and Heinz-2274) in a silty clay soil. Th...
Diabetes and Depression
Improvement of Photosynthesis by Sub1 QTL in Rice Under Submergence: Probed by Chlorophyll Fluorescence OJIP Transients
The influence of submergence on the photosynthetic activity in rice plants either possessing or not possessing Sub1 QTL i.e. Swarna and Swarna Sub1 cultivars (cv.) were evaluated under simulated complete submergence. The...
PERSPECTIVES OF THE DEVELOPMENT OF MUCOSAL VACCINES AGAINST DANGEROUS INFECTIONS ON THE BASE OF TRANSGENIC PLANTS
24-epibrassinolide enhances flower and fruit production of pepper (Capsicum annuum L.) under salt stress
Among various environmental stresses, salt stress is extensively damaging to crops production in many areas of the world. The enhancement of plant tolerance is important for plant productivity. Brassinosteroids plays an...