PROTECTIVE EFFECT OF HESPERIDIN ON OXIDATIVE STRESS, INFLAMMATION AND APOPTOSIS IN ABAMECTIN-INDUCED GASTRIC TOXICITY
Journal Title: Kocatepe Medical Journal - Year 2024, Vol 25, Issue 1
Abstract
OBJECTIVE: Abamectin is a pesticide type that is widely used in the agricultural industry today and has toxic effects because of long-term exposure. As a result of long-term exposure to abamectin, it causes an increase in oxidative stress-related inflammation and apoptosis. Hesperidin is a flavonoid found naturally in citrus fruits with antioxidant, anti-inflammatory, and anti-apoptotic effects. In this study, it was aimed to investigate the use and possible effects of hesperidin, a natural antioxidant, on abamectin-induced gastric tissue damage. MATERIAL AND METHODS: 100 or 200 mg/kg (according to the group) hesperidin was administered 30 min before the 1 mg/kg dose of abamectin for 28 days. On the 29th day, 35 animals were decapitated and their stomach tissues were removed and oxidative stress, inflammation, and apoptotic parameters were analyzed by biochemical methods. RESULTS: Abamectin increased the levels of oxidative stress, inflammation, and apoptosis parameters in gastric tissues compared to the control group (p<0,001). With the administration of hesperidin, all these abamectin-induced increases decreased (p<0,001). CONCLUSIONS: It was concluded that hesperidin has potential protective properties against the toxic effect on gastric tissues caused by abamectin exposure.
Authors and Affiliations
Sibel Çiğdem TUNCER, Cihan GÜR, Hasan ŞİMŞEK, Fatih Mehmet KANDEMİR
Keywords
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- EP ID EP731017
- DOI https://doi.org/10.18229/kocatepetip.1233652
- Views 15
- Downloads 0
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