Protective effect of hydroalcoholic extract of Teucrium polium on diabetes-induced testicular damage and serum testosterone concentration
Journal Title: International Journal of Reproductive BioMedicine - Year 2017, Vol 15, Issue 4
Abstract
Background: Diabetes has an adverse effect on spermatogenesis by rising oxidative stress. Objective: The aim of this study was to investigate the effect of Teucrium Polium extract administration on spermatogenesis and testicular structure in diabetic rats induced with Streptozotocin. Materials and Methods: 32 male Wistar rats were randomly divided into four groups (n=8/each): control group, diabetic group received distilled water, and two experimental groups included diabetic rats treated with 50 and 100 mg/body weigh of Teucrium Polium extract for 6 six weeks. After six weeks, the left testis had been removed and the morphometrical study was performed. Blood samples were collected from the ophthalmic veins of the rats and plasma levels of glucose and testosterone hormone were measured afterward. Results: The reduction in diameters of the seminiferous tubules and thickening of the wall of the seminiferous tubules (p=0.05) were seen in diabetic rats. Also, the degenerative changes in cells arrangement have been observed. Statistical analysis showed the use of Teucrium Polium significantly improved the above disorders in treatment group (100 mg/BW) in contrast to the non treated diabetic group (p=0.05), but no significant difference was seen between the experimental group treated with 50 mg/BW of Teucrium polium and diabetic group (p=0.08). These data also revealed that treatment of diabetic rats with 100 mg/BW of Teucrium Polium extract significantly improves the change in serum glucose (p=0.001) and testosterone (p=0.03). Conclusion: The results of the present study indicate that diabetes produces degenerative changes in the testis of rats and administration of Teucrium polium reduces complications resulted from diabetes.
Authors and Affiliations
Ramin Salimnejad, Ghasem Sazegar, Mohammad Javad Saeedi Borujeni, Seyed Mojtaba Mousavi, Fatemeh Salehi
Keywords
Related Articles
- EP ID EP182426
- DOI -
- Views 147
- Downloads 0
Serum ferritin concentration in early pregnancy and risk of subsequent development of gestational diabetes: A prospective study
Background: Elevated serum ferritin concentration is associated with insulin resistance and diabetes. Recently it has also been described in gestational diabetes mellitus (GDM). Objective: A prospective study was done to...
The impact of polycystic ovary syndrome on the health-related quality of life: A systematic review and meta-analysis
Background: Polycystic ovary syndrome (PCOS) has been shown to cause a reduction in health-related quality of life (HRQOL). However, the relative degree of impairment in each domain differed among samples, and it was not...
The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: An RCT
Background: The menopausal symptoms are the most common problems in postmenopausal women. Due to the side effects of hormone replacement therapy, the use of medicinal herbs has increased for the treatment of menopausal s...
Congenital adrenal hyperplasia and vanishing testis: rare case of male pseudohermaphroditism
Background: Congenital adrenal hyperplasia (CAH) and vanishing testes are uncommon diseases that can result from hormonal and mechanical factors. Classic CAH is determined by ambiguous genitalia and increase in amount of...
Association of SNP rs.2414096 CYP19 gene with polycystic ovarian syndrome in Iranian women
Background: Genetic factors are believed to play an important role in the etiology of polycystic ovarian syndrome (PCOS) which is the most common endocrinological disorder of women in their reproductive age. Androgen met...