Protective Effect of Hypothermia During Experimental Sepsis
Journal Title: Turkish Journal of Intensive Care - Year 2019, Vol 17, Issue 2
Abstract
Objective: In our study, we aimed to investigate the effect of hypothermia on survival, C-reactive protein (CRP), procalcitonin and leukocyte levels in rat models, induced with cecal ligation-perforation procedure. Materials and Methods: After formation of the sepsis, the rats were randomized as hypothermic sham, septic (32 °C-34 °C) and normothermic sham, septic (36 °C-38 °C). At the beginning of study (0 h) and at 6th hour blood was taken from all rats in all groups; CRP, procalcitonin, leukocyte levels were measured and the survival time of rats in all groups was recorded. Results: A statistically significant difference was found between the hypothermic and normothermic septic group in terms of survival time (hypothermic septic 24.3±20.2, normothermic septic group 15.9±13.5 h, p=0.039). There was no statistically significant difference for time dependent changes of CRP and procalcitonin all groups. Conclusion: It can be suggested that hypothermia in experimental sepsis might have positive effects on survival but the effect on the markers of infection is unclear and further studies are needed.
Authors and Affiliations
İclal Karaca, İlkin Çankayalı, Kubilay Demirağ, Mehmet Uyar
Keywords
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