Protective effect of nerve growth factor combined with mecobalamine on optic nerve and influence on MMP-2 and TIMP-2
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 12
Abstract
AIM: To investigate the protective effect of nerve growth factor(NGF)combined with mecobalamine on optic nerve and the influence on matrix metalloproteinase-2(MMP-2), tissue inhibitor of matrix metalloprotease-2(TIMP-2). <p>METHODS: Totally 54 patients(73 eyes)with acute angle closure glaucoma undergoing trabeculectomy was included in the study, and the patients were divided into the control group(30 cases, 35 eyes)and combination group(24 cases, 38 eyes)according to the digital table method. The patients in the control group were treated with mecobalamine, and the patients in combination group were treated with NGF combined with mecobalamine. Visual acuity, intraocular pressure, mean light sensitivity(MS), visual field mean defect(MD), retinal nerve fibre layer(RNFL)thickness, the nipple cup/disc ratio, P100 wave incubation period and amplitude of P100 wave, neuron-specific enolase(NSE), nitric oxide(NO), nitric oxide synthase(NOS), matrix metalloproteinase-2(MMP-2), metalloproteinases tissue inhibiting factor-2(TIMP-2)before and after treatment were observed in the two groups. The adverse reactions during medication were supervised. <p>RESULTS: Compared with those before treatment, visual acuity, MS, and P100 wave amplitudes increased, MD and P100 wave latency decreased(<i>P</i><0.05)after treatment, the change ranges in combination group were greater than those in control group(<i>P</i><0.05). There was no significant change in intraocular pressure, RNFL, the nipple cup/disc ratio before and after treatment in the two groups(<i>P</i>>0.05). Compared with those before treatment, serum NO, NOS, MMP-2 levels in the two groups increased, and the levels of NES, TIMP-2, TIMP-2/MMP-2 decreased(<i>P</i><0.05), but the change degrees in combination group were greater than those in control group(<i>P</i><0.05). <p>CONCLUSION: NGF combined with mecobalamine can improve postoperative visual function of glaucoma, which has certain regulatory effects on MMP-2 and TIMP-2.
Authors and Affiliations
Li Li
Keywords
Related Articles
- EP ID EP501560
- DOI 10.3980/j.issn.1672-5123.2018.12.17
- Views 148
- Downloads 0
Diagnostic value of mGCC in primary glaucoma and its correlation with pRNFL and visual fields
AIM: To analyze the diagnostic value of macular ganglion cell complex(mGCC)in primary glaucoma and explore the correlation between mGCC and peripapillary retinal nerve fiber layer(pRNFL)and visual field, in order to prov...
Detection and significance of angiogenic factors and vascular endothelial function in patients with hypertensive retinopathy of pregnancy
AIM: To investigate the changes of angiogenic factors and vascular endothelial function in patients with hypertensive retinopathy complicating pregnancy, and to analyze the relationship between the relevant factors and t...
Clinical study of SMILE on the correction of large astigmatism for 2a
AIM: To observe the surgical results of large astigmatism with small incision lenticule extraction(SMILE)for 2a. <p>METHODS: Totally 33 eyes of 17 consecutive patients were enrolled in this retrospective study, aged from...
EX-PRESS glaucoma drainage device combined with phacoemulsification for cataract patients with acute angle-closure glaucoma and ocular hypertension
AIM: To investigate the clinical efficacy and safety of EX-PRESS glaucoma drainage combined with phacoemulsification in the treatment of patients with acute angle-closure glaucoma and ocular hypertension with cataract. <...
Effect of intravitreal injection of Conbercept before PPV on complications and visual recovery in patients with PDR
AIM: To analyze the effect of intravitreal injection of Conbercept before pars plana vitrectomy(PPV)on complications and visual recovery in patients with proliferative diabetic retinopathy(PDR). <p>METHODS: Totally 94 pa...