Protective Effect of Quercetin and Curcumin against Ovarian Oxidative Stress Induced by Gossypol in Albino Female Rats
Journal Title: Journal of Applied Veterinary Sciences - Year 2022, Vol 7, Issue 4
Abstract
This study aimed to investigate the effect of gossypol on ovarian physiology, which includes oxidative stress, hormone levels, and ovarian apoptosis, and detect the positive role of quercetin and curcumin against gossypol's effect. Forty-eight albino female rats were used in the experiment, divided into six groups that included the control group (corn oil), gossypol (40 mg / kg/ b.w), quercetin (100 mg / kg /b.w), curcumin (200 mg / kg / b.w), gossypol + quercetin (40 and 100 mg / kg /b.w), gossypol + curcumin (40 and 200 mg / kg /b.w). All treatments were administered orally using a gavage needle for 35 days. The results showed that gossypol significantly decreased glutathione levels compared to the control group. However, the control group showed a significant increase in malondialdehyde levels and caspase-3 levels in ovarian tissue. In addition, treatment with curcumin (alone) significantly increased the anti-Müllerian hormone level compared to the control group. Furthermore, it was observed that in treatment with the gossypol and quercetin, there were no significant differences in caspase-3 levels compared with the gossypol group. However, there was a significant increase in glutathione levels compared with the gossypol group. As well as a significant decrease in malondialdehyde levels compared to the gossypol group. More research using different concentrations of these antioxidants (quercetin and curcumin) is needed to determine their effectiveness against gossypol effects. In conclusion, gossypol causes harmful effects on the ovaries of rats by inducing oxidative stress, decreasing glutathione levels, and increasing malondialdehyde levels.
Authors and Affiliations
Mahmood Abdullah,Fadwa Tawfeeq,
Keywords
Related Articles
- EP ID EP709625
- DOI -
- Views 43
- Downloads 0
Evaluation the Role of Effective Microorganisms (EM) on the Growth Performance and Health Parameters on Common Carp (Cyprinus carpio L.)
The study aimed to evaluate the effects of Effective microorganisms (EM) on C.carpio by studying their effect on some growth and health Parameters. The study dealt with the calculation of weekly and total weight gain, fo...
Effects of Pesticide Residues in Animal By-products Relating to Public Health
Pesticides are used on a large scale and have become unavoidable in the modern agricultural economy. Tones of them are used on a daily basis for a variety of functions, which are mostly used for agricultural activities....
Effect of Obesity on Awakening Time after Isoflurane/Sevoflurane Inhalation Anesthesia in Dogs
To elucidate the relationship between obesity, awakening time, and anesthesia in dogs, we conducted a comparative analysis of the awakening time following isoflurane and sevoflurane anesthesia in both standard-weight and...
Cysteine enhance Holstein bull’s sperm assessment quality and conception rate when added to duck egg yolk low-density lipoproteins
Spermatozoa undergo a significant transformation during the cryopreservation process, including oxidative stressors during dilution, cooling, equilibration, or freezing and thawing stages that postpone their motility and...
Effects of Amitriptyline and Ashwagandha on the Oxidative State and Acetylcholine Esterase Enzyme Activities in Rats
Amitriptyline has a long history of effectiveness in treating depression. Due to its side effects, which include oxidative stress and anticholinergic effects, it is used less frequently. Ashwagandha is a substantial herb...