Protective Effect of Quercetin and Curcumin against Ovarian Oxidative Stress Induced by Gossypol in Albino Female Rats
Journal Title: Journal of Applied Veterinary Sciences - Year 2022, Vol 7, Issue 4
Abstract
This study aimed to investigate the effect of gossypol on ovarian physiology, which includes oxidative stress, hormone levels, and ovarian apoptosis, and detect the positive role of quercetin and curcumin against gossypol's effect. Forty-eight albino female rats were used in the experiment, divided into six groups that included the control group (corn oil), gossypol (40 mg / kg/ b.w), quercetin (100 mg / kg /b.w), curcumin (200 mg / kg / b.w), gossypol + quercetin (40 and 100 mg / kg /b.w), gossypol + curcumin (40 and 200 mg / kg /b.w). All treatments were administered orally using a gavage needle for 35 days. The results showed that gossypol significantly decreased glutathione levels compared to the control group. However, the control group showed a significant increase in malondialdehyde levels and caspase-3 levels in ovarian tissue. In addition, treatment with curcumin (alone) significantly increased the anti-Müllerian hormone level compared to the control group. Furthermore, it was observed that in treatment with the gossypol and quercetin, there were no significant differences in caspase-3 levels compared with the gossypol group. However, there was a significant increase in glutathione levels compared with the gossypol group. As well as a significant decrease in malondialdehyde levels compared to the gossypol group. More research using different concentrations of these antioxidants (quercetin and curcumin) is needed to determine their effectiveness against gossypol effects. In conclusion, gossypol causes harmful effects on the ovaries of rats by inducing oxidative stress, decreasing glutathione levels, and increasing malondialdehyde levels.
Authors and Affiliations
Mahmood Abdullah,Fadwa Tawfeeq,
Keywords
Related Articles
- EP ID EP709625
- DOI -
- Views 47
- Downloads 0
Verification Of Molecular And Conventional Techniques Used In The Diagnosis Of Equine Herpes Virus In Some Egyptian Governorates
Equid herpesviruses (EHVs) affect equine health and can cause significant economic losses to the equine industry worldwide. In the current study, the circulation of two infectious equid herpesviruses (EHV-1 and EHV-4) amo...
Occurrence of Staphylococcus piscifermentans among Apparently Healthy Ruminants and Their Handlers in Maiduguri, Borno State, Nigeria
This study was conducted to determine the occurrence and antimicrobial susceptibility of Staphylococcus piscifermentans nasal colonization among apparently healthy ruminants and their handlers in Maiduguri, Borno State,...
Effect Of A Non-Steroidal Aromatase Inhibitor On Ovarian Function And Synchronicity Of Estrus In Ewes At Subtropics
Effects of non-steroidal aromatase inhibitor letrozole on ovarian function in ewe were investigated through testing the hypothesis that letrozole will arrest the growth of dominant follicles, resulting in the emergence o...
Isolation and characterization of stx1 and stx2 toxin-producing Escherichia coli in neonatal lambs with diarrhea in Nineveh governorate, Iraq
Escherichia coli causes many health problems in lambs, the most prominent of which is diarrhea, the study aimed to detect the shiga toxins genes in E.coli isolated from the suckling lambs affected with diarrhea in Nineve...
Effect of Obesity on Awakening Time after Isoflurane/Sevoflurane Inhalation Anesthesia in Dogs
To elucidate the relationship between obesity, awakening time, and anesthesia in dogs, we conducted a comparative analysis of the awakening time following isoflurane and sevoflurane anesthesia in both standard-weight and...