Protective effects of alkaloids of Cucumis metuliferus isolated from the fruit pulp on some vital organs
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 4
Abstract
The protective effects of the alkaloids of Cucumis metuliferus fruit pulp on carbon tetrachlorideinduced hepatotoxicity and gentamicin induced nephrotoxicity in adult albino rats were investigated. The result showed a significant (P<0.05) decrease in the levels of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) in CCL4 induced hepatotoxicity in rats. There was a significant (P<0.05) increase in the levels of the electrolytes (Na+, K+) which were dose dependent in gentamicin induced nephrotoxic rats compared to the controls. The dose dependent decrease in the level of urea was statistically significant (P<0.05), and there was a significant decrease in the levels of creatinine when 200 mg/kg of the alkaloid was administered to the rats alone. This result showed that alkaloids of C.metuliferus have protective effects on both the liver and kidney tissues.
Authors and Affiliations
A. A. Anyanwu, N. S. Jimam, D. A. Dangiwa, N. N. Wannang, K. D. Falang
Keywords
Related Articles
- EP ID EP49573
- DOI -
- Views 227
- Downloads 0
In vitro immunitary impact and antioxidant activity of aqueous extracts of Maprounea africana Müll (Euphorbiaceae) and Mitragyna stipulosa O.Kze (Rubiaceae)
This study aims to investigate the in vitro immunitary impacts and antioxidant activity of aqueous extracts of Maprounea africana (Euphorbiaceae) leaves and Mitragyna stipulosa (Rubiaceae) stem barks. Impact on leukocy...
A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata
Plants have been the basis of many traditional medicines throughout the world for thousands of years and continue to provide new remedies to mankind. They are one of the richest sources of compounds. Berberis aristata...
Analgesic and anti-Inflammatory activity of Tradescantia fluminensis leaves extract
Objective: The present study sought to evaluate the anti-inflammatory and analgesic activities of ethanolic extract from Tradescantia fluminensis leaves. Methods: The crude leaf extract of T. fluminensis was investigat...
Protective role of Indian medicinal plants against liver damage
India is the largest producer of medicinal plants. The medicinal plants have very important role in the health of human beings as well as animals. As per the WHO estimates, about three quarters of the world’s populatio...
Evaluation of lipogenic property of Phragmanthera capitata in diabetic rats
Objective: Phragmanthera capitata is a parasitic plant employed in the treatment of wide range of disorders in Cameroon folkloric medicine. The present study was carried out to evaluate lipogenic property of aqueous ex...