Protective Effects of Kaempferol on Isoniazid- and Rifampicin-Induced Hepatotoxicity
Journal Title: The AAPS Journal - Year 2013, Vol 15, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-013-9490-6) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Tung-Yuan Shih, Ton-Ho Young, Herng-Sheng Lee, Chung-Bao Hsieh, Oliver Yoa-Pu Hu
Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs
The Biopharmaceutics Classification System (BCS) categorizes drugs into one of four biopharmaceutical classes according to their water solubility and membrane permeability characteristics and broadly allows the predictio...
Ophthalmic drug design based on the metabolic activity of the eye: Soft drugs and chemical delivery systems
Despite its apparent easy accessibility, the eye is, in fact, well protected against the absorption of foreign materials, including therapeutic agents, by the eyelids, by the tearflow, and by the permeability barriers im...
The Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and ABCB1
CYP2D6 plays a major role in the metabolism of tamoxifen, and polymorphism of P-glycoprotein has been associated with resistance of many drug therapies. This study investigates the clinical impact of genetic variants of...
Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway
Increasing numbers of natural products have been found to possess anticancer effects. Nuclear factor erythroid-2-related factor-2 (Nrf2) is a master regulator of the antioxidative stress response, and our previous studie...
Skin oxygenation after topical application of liposome-entrapped benzyl nicotinate as measured by EPR oximetry in vivo: Influence of composition and size
New and improved drug delivery systems are the important subject of much scientific research. The development of formulations that increase skin oxygenation and of methods for measuring oxygen levels in skin are importan...