Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation
Journal Title: HASEKİ TIP BÜLTENİ - Year 2018, Vol 56, Issue 1
Abstract
Aim: The aim of this study was to evaluate the protective use of quercetin in a rat model of radiation-induced enteritis and colitis. Methods: Twenty four adult rats were randomly divided into four groups. Group SHAM was given only physiological saline, group QUER was given quercetin 50 mg/kg for 15 days, group RAD was given only irradiation and group QUER+RAD was given quercetin 50 mg/kg, and then irradiated. Twenty four hours after the exposure to radiation, all rats were euthanized for the evaluation of the ileum and colon morphology and biochemical measurements. Results: Compared with the SHAM group, the serum malondialdehyde (MDA) level was significantly higher in group RAD (p=0.004) and was significantly decreased in group QUER+RAD (p=0.015). The MDA levels in the ileum and colon tissues were significantly higher in group RAD (p=0.004 and p=0.002, respectively), while treatment with quercetin significantly reduced lipid peroxidation in both tissues in group QUER+RAD (p=0.015 and p=0.009, respectively). Compared with the control group, the serum total antioxidant status (TAS) level was significantly lower in Group RAD (p=0.002) and was significantly increased in group QUER+RAD (p=0.009). TAS in the ileum and colon tissues were significantly lower in group RAD (p=0.002 and p=0.002) and were significantly higher in both tissues in group QUER+RAD (p=0.002 and p=0.002, respectively). Conclusion: This study confirmed that, in the model of radiation-induced ileitis and colitis in rats, quercetin effectively decreased oxidative stress and inflammatory damage to both ileum and colon tissues.
Authors and Affiliations
Özcan Pişkin, Bengü Gülhan Aydın, Yılmaz Baş, Kemal Karakaya, Murat Can, Özlem Elmas, Mustafa Çağatay Büyükuysal
Keywords
Related Articles
- EP ID EP276578
- DOI 10.4274/haseki.25743
- Views 65
- Downloads 0
Frequency of Paroxysmal Nocturnal Hemoglobinuria Clone in Turkish Myelodysplastic Syndrome Group
Aim: Retrospective, cross-sectional, observational study to examine the frequency and features of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with myelodysplastic syndrome (MDS). Methods: Data were analy...
The Diagnostic Value of Irisin and Visfatin in Experimental Testicular Torsion
Aim: Testicular torsion (TT) is one of the most important causes of acute scrotum in children and young men. Very scarce number of serum laboratory parameters might be used in the early diagnosis of patients with TT. We...
Flow-Mediated Dilatation and Asymmetric Dimethylarginine Do Not Predict Mortality in Peritoneal Dialysis Patients
Aim: Asymmetric dimethylarginine (ADMA) is associated with increased coronary artery disease risk through endothelial dysfunction in dialysis patients. We aimed to investigate the role of flow-mediated dilatation (FMD),...
Effects of Aspirin Use on Post-operative Complications in Patients Undergoing Bilateral Total Thyroidectomy
Aim: The aim of this study was to assess the effects of preoperative aspirin use on postoperative complications, especially risk of bleeding, in patients undergoing bilateral total thyroidectomy. Methods: A total of 201...
A Rare Cause of Upper Gastrointestinal Bleeding: Brunner’s Gland Hamartoma
Brunner’s gland hamartoma is a submucosally localized and rarely encountered benign condition. Majority of cases are asymptomatic. Generally, it is diagnosed incidentally during endoscopic examinations of the upper gastr...