Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation
Journal Title: HASEKİ TIP BÜLTENİ - Year 2018, Vol 56, Issue 1
Abstract
Aim: The aim of this study was to evaluate the protective use of quercetin in a rat model of radiation-induced enteritis and colitis. Methods: Twenty four adult rats were randomly divided into four groups. Group SHAM was given only physiological saline, group QUER was given quercetin 50 mg/kg for 15 days, group RAD was given only irradiation and group QUER+RAD was given quercetin 50 mg/kg, and then irradiated. Twenty four hours after the exposure to radiation, all rats were euthanized for the evaluation of the ileum and colon morphology and biochemical measurements. Results: Compared with the SHAM group, the serum malondialdehyde (MDA) level was significantly higher in group RAD (p=0.004) and was significantly decreased in group QUER+RAD (p=0.015). The MDA levels in the ileum and colon tissues were significantly higher in group RAD (p=0.004 and p=0.002, respectively), while treatment with quercetin significantly reduced lipid peroxidation in both tissues in group QUER+RAD (p=0.015 and p=0.009, respectively). Compared with the control group, the serum total antioxidant status (TAS) level was significantly lower in Group RAD (p=0.002) and was significantly increased in group QUER+RAD (p=0.009). TAS in the ileum and colon tissues were significantly lower in group RAD (p=0.002 and p=0.002) and were significantly higher in both tissues in group QUER+RAD (p=0.002 and p=0.002, respectively). Conclusion: This study confirmed that, in the model of radiation-induced ileitis and colitis in rats, quercetin effectively decreased oxidative stress and inflammatory damage to both ileum and colon tissues.
Authors and Affiliations
Özcan Pişkin, Bengü Gülhan Aydın, Yılmaz Baş, Kemal Karakaya, Murat Can, Özlem Elmas, Mustafa Çağatay Büyükuysal
Keywords
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- EP ID EP276578
- DOI 10.4274/haseki.25743
- Views 66
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