PROTECTIVE EFFECTS OF VITAMIN E ON NITAZOXANIDE ADVERSE EFFECTS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 3
Abstract
This study to evaluate the protective effect of Vitamin E (18mg/kg, P.O. once daily) on Nitazoxanide adverse effects (18mg/kg, P.O. once daily) and its effect on liver, kidney, blood and antioxidant enzymes for three weeks. Then tissue and blood samples were collected on 1st, 7th, 14th and 21th days post-treatment to assess the protective effect of Vitamin E. Our results indicated that Vitamin E has hepato-nephro-protective and there was a decrease in the elevation of liver enzymes caused by Nitazoxanide like ALT, AST and ALP and kidney parameters like creatinine and urea, and there was a normalize in all blood parameters which decrease by Nitazoxanide and finally there was a significant increase in antioxidant enzymes like CAT, SOD, GPX and a significant decrease in MDA, beside showing decrease in fatty change of liver caused by Nitazoxanide administration, as demonstrated by hepatic histopathology. Also, showing decrease in aggregation of chronic inflammatory cell caused by Nitazoxanide administration, as demonstrated by kidney histopathology. Therefore, Vitamin E should be taken with Nitazoxanide to decrease its side effects.
Authors and Affiliations
Dr. Noha Naiem
Keywords
Related Articles
- EP ID EP620088
- DOI -
- Views 120
- Downloads 0
INFECTION CONTROL PRACTICE DURING ANESTHESIA
Anesthesia providers commonly cross-contaminate their workspace and subsequently put patients at risk for a health care−acquired infection. The primary objective of this project was to determine if education and implemen...
TREATMENT OF PSYCHOSIS DISRORDER
Psychosis is refers to an abnormal condition of mind in which person loss his contact with reality and the person suffures from psychosis is called as psychotic. Psychosis makes people confuse or misintepret what is goin...
ANAL FISSURE AND THROMBOSED EXTERNAL HEMORRHOIDS BEFORE AND AFTER DELIVERY
One third of patients have anal lesions after delivery. Fifty-seven percent of these patients have thrombosed external hemorrhoids, and 43 percent have an anal fissure. Thrombosed external hemorrhoids occur during and im...
TOTAL PHENOLIC CONTENTS AND FERRIC-REDUCING ANTIOXIDANT POWER FROM DIFFERENT PARTS OF MULTIPURPOSE TREE (Moringa oleifera Lam).
Moringa oleifera played an important role in controlling oxidation caused by free radicals. Thus served as remedy to oxidative damages. This study was aimed to assess antioxidant activity and estimate total phenolic cont...
POLYUNSATURATED FATTY ACIDS INTAKE AND ITS ASSOCIATION WITH BREAST CANCER AMONG PATIENTS ATTENDING THE RADIATION AND ISOTOPE CENTER IN KHARTOUM STATE
Objective: To determine any association between dietary polyunsaturated fatty acids (PUFAs) intake by Sudanese women attending the Radiation and Isotope Center in Khartoum and the incidence of breast cancer (BC). Methodo...