Protective role of curcumin in maximal electroshock induced seizures, memory impairment and neurotransmitters in rat brain
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2008, Vol 2, Issue 1
Abstract
Central nervous system disorders are of great concern in the present day world due to increasing stress and changing living conditions. Since epilepsy is one of the most prevalent CNS disorders, and as a number of side effects are associated with the present antiepileptic drug treatments, the presented research was designed to evaluate the effect of curcumin on generalized tonic clonic (GTC) seizures, together with its eff ect on memory retention in seizure induced rats, and the role of monoamines in protection from seizures and memory impairment. To investigate the effect on GTC, Maximal electro shock (150mA intensity for 0.2 sec) was administered using electro convulsiometer after 14 days of treatment with curcumin (5 and 10 mg/kg). Rats were trained for conditioned avoidance response before the initiation of treatment, and the effect on memory was studied after the induction of epilepsy using a conditioned avoidance response task. Fluorimetric estimations of norepinephrine, dopamine and serotonin in cerebral cortex, cerebellum, hippocampus, pons and hypothalamus made it evident that curcumin exerted a potential antiepileptic and memory retentive effects, with considerable influence on the brain monoamine levels.
Authors and Affiliations
Chimakurthy Jithendra, Talasila Murthy, Lokesh Upadyay
Keywords
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