PROTECTIVE ROLE OF LYCOPENE ON CADMIUM INDUCED LUNG INJURY
Journal Title: IJAR-Indian Journal of Applied Research - Year 2019, Vol 9, Issue 7
Abstract
The present study has been undertaken to evaluate the protective efficacy of lycopene on cadmium induced toxicity in lungs of albino mice. Albino mice were divided into four groups. Group I mice were kept as control. Group II animals were administered a single dose of cadmium chloride (0.32mg/kg bw) intraperitoneally. Group III animals were injected with 20 mg/kg bw of olive oil (positive control). Group IV animals were injected a single dose of CdCl followed by a chronic dose of lycopene (20mg/kg bw). 2 Autopsies were done at the intervals of 1, 5, 10 and 15 days post treatment. Cadmium treatment leads to decrease in weight of lungs. Histopathological analysis of treated lungs revealed atrophy, hyperaemia, lymphocytic infiltration and thickening of bronchiolar wall. Lycopene administration to mice increased the weight of lungs and showed significant protection in the alleviation of cadmium induced pulmonary injury.
Authors and Affiliations
P. Vijaya, Suman Sharma
Keywords
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