Protective role of marine macroalgae extracts against STZ induced diabetic rats
Journal Title: Journal of Coastal Life Medicine - Year 2017, Vol 5, Issue 12
Abstract
Objective: To study the anti-diabetic activity of marine macroalgae extracts (n = 31), purification and characterization of sulphated galactopyran (SGP) from Gracilaria opuntia (FM4) in diabetic rats. Methods: The animals were separated into groups and STZ (55 mg/kg body weight) was used to induce diabetics. Glucose, HbA1c, insulin, C-peptide levels and in vivo antioxidant levels were estimated and histopathological studies were done in STZ-induced diabetic and marine macroalgae treated rats. Results: Based on glucose and HbA1c levels and in vivo antioxidant levels, among the 31 marine macroalgae extracts, FM4 has showed high anti-diabetic activity. Hence, FM4 was purified and characterized by 1H-NMR spectra and FT-IR as sulphated galactopyran. During the survival analysis, SGP at dose of 100 mg/kg showed significant (P < 0.05) survival rate and elevations in C-peptide and insulin levels. The histopathological modulations of SGP were observed in diabetic rat tissues such as liver, kidney and brain. Hence obtained results reveal that SGP treated diabetic rats has significant changes in C-peptide and insulin levels which regulates the blood glucose levels and recovered the histopathological changes. Conclusions: Marine macroalgae have significant anti-diabetic activity. Hence, they could be used as nutraceutical supplement or natural green remedy against diabetes mellitus.
Transferrin gene polymorphisms and population genetic studies of Atlantic cod (Gadus morhua)
Objective: To detect single nucleotide polymorphisms (SNPs) in the cod transferrin gene by comparing the sequences from Norwegian (North East Atlantic Ocean) and Canadian (North West Atlantic Ocean) specimen, and to quan...
Isolation of actinomycetes from mangrove and estuarine sediments of Cochin and screening for antimicrobial activity
Objective: To isolate and screen actinomycetes for antimicrobial activity from mangroves and estuarine soil samples of Cochin. Methods: In the present study, sediment samples collected from mangroves and various stations...
Study on enzymes of industrial interest in digestive viscera: Greater amberjack (Seriola dumerili)
Objective: To investigate the presence of industrial enzymes (trypsin and chymotrypsin) as well as collagenolytic and fibrinolytic activities of the neglected processing waste of greater amberjack Seriola dumerili (S. du...
Protective effects of Cuminum cyminum L. essential oil on ethylene glycol induced nephrolithiasis in mice
Objective: To investigate the protective effect of Cuminum cyminum (C. cyminum) essential oil on ethylene glycol induced nephrolithiasis in mice. Methods: The study comprised of the following four different groups of six...
Antioxidant, phytotoxic and cytotoxic activity of methanolic extract of Trigonella foenum-graecum
Objective: To analyze the methanol extract of Trigonella foenum-graecum (T. foenumgraecum) for antioxidant, phytotoxic and cytotoxic activity. Methods: The powder of T. foenum-graecum was extracted in diluted methanol wi...