Proteomic characterization of platelet-derived extracellular vesicles induced by different activation pathways
Journal Title: Chinese Journal of Blood Transfusion - Year 2022, Vol 35, Issue 12
Abstract
Activated platelets secrete bioactive molecules and extracellular vesicles. Platelet-derived extracellular vesicles(PEVs), which are rich in proteins, have become important mediators of intercellular communication and cargo exchange, being involved in not only hemostasis and thrombosis, but also in immunity and tissue repair. In past decades, many advances have been made in the isolation, characterization and application of PEVs. Platelet activation modes influence the proteomic features of formed extracellular vesicles. The activation ways may be closely related to functional differences. This review summarized the proteomics and functions of PEVs induced by different platelet activation pathways.
Authors and Affiliations
Yang GAO, Caoyi LIU, Yu LIU
Keywords
Related Articles
- EP ID EP738443
- DOI 10.13303/j.cjbt.issn.1004-549x.2022.12.020
- Views 65
- Downloads 0
Hemophilia A with reduced coagulation factor Ⅺ: a case report and literature review
Objective To investigate the possible molecular pathogenesis of a child with hemophilia A accompanied by coagulation factor Ⅺ reduction by testing coagulation-related indicators and genotyping in the child and his family...
The capacity evaluation and utilization strategy of the platelet donor database with known HLA/HPA genotype in Shaanxi
Objective To evaluate the appropriate optimal capacity and matching probability of the platelet donor database with known HLA/HPA genotype in Shaanxi aera, and provide data support for subsequent construction, maintenanc...
Application of monocyte monolayer assay on hemolytic disease of fetus and newborn caused by IgG anti-M
Objective To elucidate the prediction ability of monocyte monolayer assay(MMA) used in hemolytic disease of fetus and newborn(HDFN) caused by IgG anti-M. Methods Plasma from eight pregnant women containing IgG anti-M wer...
Analysis and prospect of platelet compatible transfusion
Platelet compatible transfusion can effectively solve the immune mediated platelet transfusion refractoriness (PTR), save platelet resources and improve blood safety. This paper comments and prospects the compatibility m...
Establishment and evaluation of intraoperative blood transfusion prediction model based on random forest algorithm
Objective To predict the risk factors of intraoperative blood transfusion by establishing a random forest algorithm prediction model, and to evaluate its prediction performance in clinical. Methods A total of 48 176 pati...