PROTEOMIC STUDIES OF CHEMICAL CONSTITUENTS OF COMMELINA COMMUNIS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2018, Vol 8, Issue
Abstract
The present research work was aimed to discover anti-viral and anti-dengue activity of the phytochemical constituents present in Commelina communis using Molecular docking studies. In this research work, we have screened 10 chemical constituents from Commelina communis through docking studies, in an effort to develop novel anti-dengue and anti-viral activity, the target enzymes were chosen for the study is 4M9K, 3P54, 2V33, 5FC8 and 5B1C using Argus lab 4.0.1 software. Among the 10 screened compounds of Commelina communis, shows best to moderate (-9.49194kcal/mol to –5.61913kcal/mol) binding energy and various bonding interactions against the targeted proteins. On the basis of docking study results, it can be concluded that chemical constituents of Commelina communis, serve as promising chemical probes to design therapeutic agents with anti-dengue, and antiviral properties.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP504431
- DOI -
- Views 105
- Downloads 0
A LC-MS/MS METHOD FOR THE QUANTIFICATION OF CLAVULANATE IN HUMAN PLASMA BY NEGATIVE ION MODE AND ITS PHARMACOKINETIC APPLICATION
A high performance liquid chromatography tandem mass spectrometric simple protein precipitation method for the estimation of Clavulanate potassium (CLV), in human plasma in Negative ion mode was developed and validated b...
Formulation and Evaluation of L-arginine Sustained Release Tablets
L-Arginine is an amino acid that has numerous functions in the body. In the body L-Arginine is used to make nitric oxide which reduces blood vessels Stiffness, increases blood flow and improves blood vessel function. L-A...
SURVELLIANCE OF BOVINE MILK SAMPLES AND DETERMINED ITS IMMUNOLOGICAL ACTIVITY OF LACTOFERRIN
Abstract Milk is a very complex product and reported more than hundred separate chemical compounds. The major components of milk are water, casein, whey proteins, fat, lactose and minerals. These components should be var...
FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF DOFETILIDE TABLET
Abstract In the present research work floating pulsatile drug delivery system of dofetilide were prepared using various grades of methocel polymers. Initially analytical method development was done for the drug molecule....
ANTIPYRETIC ACTIVITIES OF THE AQUEOUS AND ETHANOL EXTRACTS OF FLOWER HEADS OF MATRICARIA RECUTITA AGAINST YEAST EXTRACT INDUCED PYREXIA MODEL IN MICE
Abstract Medicinal plants have always been associated with cultural and traditional believes and knowledge. Traditional Medicine constitutes 75-80% of the world’s population, mainly in developing countries, for various p...