PROTEOMIC STUDIES OF CHEMICAL CONSTITUENTS OF COMMELINA COMMUNIS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2018, Vol 8, Issue
Abstract
The present research work was aimed to discover anti-viral and anti-dengue activity of the phytochemical constituents present in Commelina communis using Molecular docking studies. In this research work, we have screened 10 chemical constituents from Commelina communis through docking studies, in an effort to develop novel anti-dengue and anti-viral activity, the target enzymes were chosen for the study is 4M9K, 3P54, 2V33, 5FC8 and 5B1C using Argus lab 4.0.1 software. Among the 10 screened compounds of Commelina communis, shows best to moderate (-9.49194kcal/mol to –5.61913kcal/mol) binding energy and various bonding interactions against the targeted proteins. On the basis of docking study results, it can be concluded that chemical constituents of Commelina communis, serve as promising chemical probes to design therapeutic agents with anti-dengue, and antiviral properties.
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