Proton pump inhibitor use and its relation to serum magnesium levels among hemodialysis patients: A single centre study in a South Indian tertiary care hospital
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2018, Vol 3, Issue 2
Abstract
Introduction Proton pump inhibitors PPI are commonly used in clinical practice for various indications such as gastritis peptic ulcer and gastroesophageal reflux disease In Observational studies Hypomagnesaemia has been associated with PPI use in general population Hypomagnesaemia is a significant predictor of mortality especially in HD patients There is a lack of data regarding association of PPI with hypomagnesemia in dialysis population Materials and Method Study was conducted in Tertiary care hospital using a pre dialysis serum samples by colorimetrickit method Mean of two consecutive serum Mg levels measured at 6 weeks interval was calculated for further analysis Clinical demographic data along with duration of PPI use in months were recorded Patients on diuretics chronic diarrhoea and HD for Acute Kidney Injury were excluded Student ttest was used for comparison between PPI users and non userssinglecentre observational design on 87 prevalent HD patients on twice weekly and thrice weekly maintenance HD with regular PPI use for 2 weeks Serum Magnesium Mg level was determined using Results55 patients were on Proton Pump Inhibitors at the time of study All patients were dialyzed with dialysate Mg of 12mgdL 07 mmolL Average duration of PPIs use was 6 months 6 145 months Serum Mg levels among PPI users was 25 mgdL and nonusers was 24 mgdL No correlation was found between serum Mg levels and duration of PPIs use p 08Conclusion In our study we did not find any association between hypomagnesemia and PPI use in hemodialysis patients As our study was single centered small population with short follow up further well defined long term Randomized controlled trials on Mg levels with PPI use are neededKeywordsHypomagnesemia Proton pump inhibitor Chronic kidney disease Hemodialysis
Authors and Affiliations
Murali M, Pradeep Shenoy M, Shobhana Nayak Rao, Sudha M
Keywords
Related Articles
- EP ID EP481717
- DOI 10.18231/2456-9542.2018.0016
- Views 90
- Downloads 0
Polyvalent Anti Snake Venom: Adverse drug reactions in children
Snakebite is one of the important causes of mortality in our country. Anti-snake venom (ASV) is administered in the management of snake bite. In India polyvalent ASV is used. There is risk of anaphylactic reaction. It sh...
Study of invitro antimicrobial activity of biogenically synthesised silver nanoparticle using leaf extract of aponogeton natans
Different biological methods are gaining recognition for the synthesis of silver nanoparticles (Ag-NPs) due to their multiple applications. One of the most important applications of Ag-NPs is their use as an antibacteria...
Assessment of knowledge, attitude & practices towards immunization against Hepatitis B virus infection amongst medical students in a medical college in Mangalore
Introduction: Infection by Hepatitis B virus is the cause of chronic hepatitis, liver cirrhosis and hepato-cellular carcinoma worldwide. It’s estimated that almost 257 million of the world population have contracted the...
Impact of self-medication among first and second year para medical students of a teaching hospital in Dakshina Kannada, South India: A comparative assessment
Introduction Selfmedication is said to be widely practiced among students perceiving careers in medical and health related courses and learning pharmacology might further influence this practice Hence this study is done...
Study of prescription pattern in medicine intensive care unit of a rural medical college and hospital of Himachal Pradesh: A retrospective observational study
Introduction: A large number of drugs are prescribed to the patients in Intensive Care Unit (ICU), as the condition of most patients is critical. Materials and Method: we conducted a retrospective observational study and...