Przegląd zastosowań spektroskopii w zakresie bliskiej podczerwieni w analizie wilgotności śladowej w produktach leczniczych weterynaryjnych immunologicznych
Journal Title: Wiadomości Chemiczne - Year 2016, Vol 70, Issue 11
Abstract
However, the infrared radiation has been discovered more than 200 years ago, near-infrared spectroscopy (NIRS), as a useful method, was recognized in the 1960s. Currently, under the influence of technological development, quantitative and qualitative methods require short time and precision of measurements. NIRS has a growing recognition in the industry, particularly pharmaceutical where each component of the finished product has impact on the quality and safety of the product. Freeze-dried immunological veterinary medicinal products (IVMPs), despite high specificity, contain not too complicated matrices for analysis. Karl Fischer titration is routinely used as accurate and effective method to determine the water content in the IVMPs, but the use of near-infrared spectroscopy allows to avoid the adverse impact of environmental factors on the measurements. However, for NIRS, there is a need to create a calibration model which will be precise for high diversity of samples. The most important is the optimization of the model by eliminating the factors that might influence the measurement of water content. Quantification methods most frequently used are: MLR, PLS and PCR, which are preceded by the appropriate pretreatments (derivatives of Savitzky Golay).
Authors and Affiliations
Krzysztof Bulenger, Bogumił Biernacki, Dorota Marta Krasucka, Jakub Szumiło, Beata Cuvelier
Keywords
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