Public acceptance of a hypothetical Ebola virus vaccine in Aceh, Indonesia: A hospital-based survey
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2017, Vol 7, Issue 4
Abstract
Objective: To determine the acceptance towards a hypothetical Ebola virus vaccine (EVV) and associated factors in a non-affected country, Indonesia. Methods: A hospital-based, cross-sectional study was conducted in four regencies of Aceh, Indonesia. A set of pre-tested questionnaires was used to obtain information on acceptance towards EVV and a range of explanatory variables. Associations between EVV acceptance and explanatory variables were tested using multi-steps logistic regression analysis and the Spearman's rank correlation. Results: Participants who had knowledge on Ebola virus disease (EVD) were 45.3% (192/424) and none of the participants achieved 80% correct answers on the knowledge regarding to EVD. About 73% of participants expressed their willingness to receive the EVV. Education attainment, occupation, monthly income, have heard regarding to EVD previously, socioeconomic level, attitude towards vaccination practice and knowledge regarding to EVD were associated significantly with acceptance towards EVV in univariate analysis (P < 0.05). In the final multivariate model, socio-economic level, attitude towards vaccination practice and knowledge regarding to EVD were the independent explanatory variables for EVV acceptance. Conclusions: The knowledge of EVD was low, but this minimally affected the acceptance towards EVV. However, to facilitate optimal uptake of EVV, dissemination of vaccine-related information prior to its introduction is required.
Antipyretic and antimalarial activities of crude leaf extract and fractions of Enicostema littorale
Objective: To evaluate the antiplasmodial and antipyretic activities of whole plant extract and fractions of Enicostemma littorale (E. littorale) for ascertaining the folkloric claim of its antimalarial and antipyretic a...
Liver tumours in children: diagnostic and therapeutic approach in the Tropics
Liver tumours in children are rare and their prognosis are poor. Through a cross and retrospective study, we examined the epidemiological, clinical and therapeutic aspects on a number of patients in our hospital to try a...
Comparison of chitosan, alginate and chitosan/alginate nanoparticles with respect to their size, stability, toxicity and transfection
Objective: To to compare the chitosan/alginate, chitosan and alginate nanoparticles as plasmid vectors, to determine the morphological characteristics, size and physicochemical properties of nanoparticle-pEGFP complexes...
In vitro antiplasmodial activity of marine sponge Clathria vulpina extract against chloroquine sensitive Plasmodium falciparum
Objective: To explore the antiplasmodial potential of marine sponge Clathria vulpina (C. vulpina) against chloroquine sensitive Plasmodium falciparum (P. falciparum). Methods: The marine sponge C. vulpina was collected f...
Estimation of genotoxic and mutagenic potential of latex and methanolic leaves extract of Euphorbia helioscopia by comet assay and Ames test
Objective: To investigate the genotoxic and mutagenic potentials of Euphorbia helioscopia (Family: Euphobiaceae) latex and methanolic leaves extract. Methods: Comet assay was adopted to investigate genotoxicity potential...