PULSATILE DRUG DELIVERY SYSTEM – A REVIEW
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 12
Abstract
Controlled drug delivery systems have acquired a center stage in the arena of pharmaceutical R&D business. Such systems offer temporal or spatial control over the release of drug and grant a new lease on life to a drug molecule in terms of patentability. Controlled drug delivery systems release the drug with constant or variable rates. However, there are certain conditions for which such a release pattern is not suitable. These conditions demand release of drug after a lag time. In other words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. There are certain conditions which demands such systems they include; many body functions that follow circadian rhythm. A number of hormones like rennin etc shows daily fluctuations in the blood stream. Then the same is observed in certain diseases like the bronchial asthma, ulcer , etc display time dependence. This system is also preferable for the drug which produces biological tolerance and the drugs which undergo extensive first pass metabolism. All these conditions demand for a time programmed therapeutic scheme releasing the right amount of drug at the right time. This requirement is fulfilled by pulsatile drug delivery system only. Thus such systems is characterized by a lag time that is an interval of no drug release followed by rapid drug release.
Authors and Affiliations
Sinchu Yesudanam
Keywords
Related Articles
- EP ID EP666079
- DOI -
- Views 180
- Downloads 0
ALCOHOLIC EXTRACT OF ALOE VERA AS ANTIBACTERIAL AGENT AGAINST THE GRAM-POSITIVE BACTERIA STAPHYLOCOCCUS AUREUS IN MEDANI CITY - GEZIRA STATE – SUDAN - 2018
The plant Aloe vera was used historically as a topical to heal wounds, various skin conditions and orally as a laxative. The Gram-positive bacterium Staphylococcus aureus is considered to be the most pathogenic species o...
PREVALENCE AND PROGRESSION OF DIABETIC RETINOPATHY IN PATIENTS NEWLY DIAGNOSED WITH TYPE 2 DIABETES MELLITUS
Context: Many diabetic patients fear visual loss as the worst consequence of diabetes. In most studies the main eye pathology is assigned as the cause of visual impairment. Diabetic retinopathy, the most frequent cause o...
A CONCEPTUAL REVIEW OF AUSHADHA SEVANA KALA IN AYURVEDA SIDDHANTA
Aushadh Sevan Kala is the type of Avasthika Kala meant for the proper time of drug administration. Trisutra Ayurved is of prime importance while treating a patient. Hetu (causative factors), linga (signs and symptoms) an...
BILATERAL HIGH GRADE VESICOURETERIC REFLUX: A CASE REPORT
Background: Vesicoureteral reflux (VUR) is defined as the retrograde flow of urine from the bladder to the ureter and the upper urinary tract. Materials and Method: We report a case of a 1.5yr old female child, presentin...
IS ATTENTION DEFICIT /HYPERACTIVITY DISORDER (ADHD) A DIAGNOSIS OR A SYMPTOM COMPLEX? EXPERIENCE FROM PEDIATRIC ORTHOPEDIC PRACTICE
Objective: Attention deficit hyperactivity disorder (ADHD) is a group of behavioral symptoms that include hyperactivity and impulsiveness. The etiological understanding is somehow controversial. We aimed to study the eti...