PULSATILE DRUG DELIVERY SYSTEM – A REVIEW
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 12
Abstract
Controlled drug delivery systems have acquired a center stage in the arena of pharmaceutical R&D business. Such systems offer temporal or spatial control over the release of drug and grant a new lease on life to a drug molecule in terms of patentability. Controlled drug delivery systems release the drug with constant or variable rates. However, there are certain conditions for which such a release pattern is not suitable. These conditions demand release of drug after a lag time. In other words, it is required that the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. There are certain conditions which demands such systems they include; many body functions that follow circadian rhythm. A number of hormones like rennin etc shows daily fluctuations in the blood stream. Then the same is observed in certain diseases like the bronchial asthma, ulcer , etc display time dependence. This system is also preferable for the drug which produces biological tolerance and the drugs which undergo extensive first pass metabolism. All these conditions demand for a time programmed therapeutic scheme releasing the right amount of drug at the right time. This requirement is fulfilled by pulsatile drug delivery system only. Thus such systems is characterized by a lag time that is an interval of no drug release followed by rapid drug release.
Authors and Affiliations
Sinchu Yesudanam
Keywords
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