Purslane protects against the reproductive toxicity of carbamazepine treatment in pilocarpine-induced epilepsy model
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 4
Abstract
Objective: To investigate the protective effect of purslane with carbamazepine treatment. Methods: Male albino rats were modulated by pilocarpine to be epileptic. Both the normal and epileptic rats were treated with carbamazepine, purslane or carbamazepine plus purslane, with separate non-treated control groups for both normal and epileptic rats. Results: The data from the current study showed amelioration in amino acids and electrolytes in the epileptic rats treated with purslane and carbamazepine, with this amelioration occurring without decreasing the fertility hormones (testosterone, dehydroepiandrosterone, luteinizing hormone and follicle stimulating hormone). Purslane treatments also prevented the increase in estradiol. The decreased epileptic hyperexcitability with purslane was evidenced by decreased glial fibrillary acidic protein and lipid peroxidation. Conclusions: Natural products like purslane could be used with the highly repetitive drugs like carbamazepine to reduce or prevent its side-effects.
Authors and Affiliations
Widad Makhdour i Al-Bishri, Eman Salah Abdel-Reheim, Amr Reda Zaki
Keywords
Related Articles
- EP ID EP253321
- DOI 10.1016/j.apjtb.2017.01.003
- Views 60
- Downloads 0
Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice
Objective To explore the immunomodulatory properties of 80% ethanol extract and butanol fraction of Gentiana olivieri (G. olivieri) Griseb on Balb/C mice. Methods The study was performed with basic models of immunomod...
Phytochemical investigation, antioxidant and wound healing activities of Citrullus colocynthis (bitter apple)
Objective: To undertake metabolite profiling of various plant parts of Citrullus colocynthis, and assess antioxidant and wound healing activities of fractions for therapeutical applications. Methods: Extracts from leaves...
Efficacies of four plant essential oils as larvicide, pupicide and oviposition deterrent agents against dengue fever mosquito, Aedes aegypti Linn. (Diptera: Culicidae)
Objective: To evaluate larvicidal, pupicidal and oviposition deterrent activities of four plant essential oils from Alpinia galanga (L.) Willd rhizome, Anethum graveolens L. (An. graveolens) fruit, Foeniculum vulgare Mil...
Physicochemical properties, antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids
Objective: To study physicochemical properties, antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids. Methods: The substituted 4-bromomethyl coumarins were synthesized in first step by the cy...
Sequence analysis of Turkish field strains of bovine torovirus shows unique amino acid changes in the partial M gene
Objective: To investigate the presence, prevalence and phylogenetic classification of bovine torovirus (BToV). Methods: Stool samples from 72 calves, which were negative for primary gastroenteritis agents, were examined...