PYRAZOLINES AS POTENT ANTITUBERCULAR AND CYTOTOXIC AGENTS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 6
Abstract
Objective: Pyrazolines are known to exhibit different biological and pharmacological properties such as anticancer, antibacterial, antifungal and antitubercular activities. Chalcones with an enone group between two aromatic rings exhibit remarkable pharmacological activities such as antiinflammatory, antibacterial, antitumor, antifungal, and antimalarial activity. A series of pyrazolines from chalcones have been synthesized and evaluated for antitubercular and cytotoxic activity studies.Methods: Chalcones [3-substituted phenyl-1-(p-tolyl)prop-2-en-1-one] were synthesized from various substituted aldehydes and 4-methyl acetophenone and cyclized into pyrazolines [5-substituted phenyl-3-(p-tolyl)-4,5-dihydro-1H-pyrazole] using hydrazine hydrate. Antitubercular and cytotoxic activity studies were carried out.Results: Antitubercular and cytotoxic activity studies of synthesized pyrazoline revealed that some compounds have showed promising activity.Conclusion: The observed results proved that pyrazolines are found to be interesting lead molecules for further synthesis as antitubercular and cytotoxic agents.
Authors and Affiliations
Ishwar Bhat K, Abhishek Kumar
Keywords
Related Articles
- EP ID EP605346
- DOI 10.22159/ajpcr.2017.v10i6.17344
- Views 109
- Downloads 0
HISTOLOGICAL AND IMMUNOLOGICAL STUDIES ON THE PROTECTIVE EFFECT OF EUCALYPTUS CAMALDULENSIS AGAINST ROUNDUP-INDUCED HEPATOTOXICITY IN FROGS
Objective: Roundup (RUP) is a prominent utilized worldwide herbicide. Possible toxicity of RUP is a considerable debate. We studied the possible mode of RUP cytotoxicity and the antitoxic effects of Eucalyptus camaldulen...
FORMULATION DEVELOPMENT AND EVALUATION OF PRONIOSOMAL GEL OF ETHINYLESTRADIOL AND LEVONORGESTREL FOR ANTIFERTILITY TREATMENT
Objective: The purpose of this research was to develop and formulate proniosomal gel drug delivery system of ethinylestradiol and levonorgestrel for antifertility treatment that is capable of efficiently delivering entra...
MOLECULAR DOCKING OF HYRTIMOMINE A-K FROM MARINE SPONGE HYRTIOS SPP. AS ANTICANCER TARGET OF PHOSPHOINOSITIDE-DEPENDENT KINASE 1
Objective: The hyrtimomine A-K class of indole-based compounds extracted from Hyrtios spp. of sponges from the sea has not been studied for their anticancer properties. Phosphoinositide-dependent kinase 1 (PDK1) is a mas...
ROLE OF APELIN/MONOCYTE CHEMOATTRACTANT PROTEIN-1, INFLAMMATORY, APOPTOTIC MARKERS IN THE REGULATION OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Objective: The objective of this study is to investigate blood nuclear factor κB (NF-κB), apelin, Lipid peroxide product ; thiobarbituric acid (TBA) malonaldehyde (MDA), monocyte chemoattractant protein-1 (MCP-1), B-ce...
COMPARATIVE ESTIMATION OF SALIVARY TOTAL ANTIOXIDANT CAPACITY IN PERIODONTAL HEALTH AND CHRONIC PERIODONTITIS - A PILOT STUDY
Objective: Gram-negative bacteria provoke polymorphonuclear leukocyte (PMN) to release reactive oxygen species in chronic periodontitis (CP). Inability to maintain a balance between oxidative stress and antioxidant level...