Quality of Life in Rheumatoid Arthritis patients taking combination DMARDs
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Objective: To assess the QOL of RA patients taking non biological combination DMARDs Material & Methods Study Design: Open Label Study Treatment naïve or chronic cases of RA in age group of 18-60 years of both sex with RA duration >= 6 months and Disease Activity Score (DAS28) >3.2 were included. 131 patients were taken and categorized in 2 study groups for taking of combination of DMARDs. Group-1 patients (n=68) were taking/given. Methotrexate weekly with hydroxychloroquine oral daily. Group-2 patients (n=63) were taking/given Methotrexate weekly as in group-1 patients with tablet salfasalazine oral daily. The patients who were already on these combination DMARDs were also included. Observations: The mean duration of disease was 4 years in both the groups. On comparing the baseline and end study values, there was significant improvement in all the domains of domains of WHO-QOL BREFT within the groups. There was significant improvement in quality of life in all the domains of WHOQOL BREF within the groups. However, when comparing domain score between treatment groups, both before and after the treatment, the difference is statistically not significant, except in environmental domain score at the end of the study. Also, within the group, the mean scores of various domains of QOL is significantly increasing at the end of th 5th follow up with insignificant differences seen for social domain in group-1 only. Conclusion: The study recommends that use of conventional DMARDs in different combinations help in improvement of QOL of RA patients and therefore these drugs should be started early in the course of the disease
Authors and Affiliations
Paramjeet Singh
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