Quantification of Galantamine in Sternbergia Species by High Performance Liquid Chromatography
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2019, Vol 16, Issue 1
Abstract
Objectives: This study describes the qualitative and quantitative analysis of galantamine in Sternbergia species growing in Turkey. Materials and Methods: Galantamine was isolated from Sternbergia fischeriana bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in Sternbergia lutea subsp. lutea, S. lutea subsp. sicula, Sternbergia candida, S. fischeriana, and Sternbergia clusiana using a specially developed and validated high performance liquid chromatography (HPLC) method. Results: S. lutea subsp. sicula had the highest content of galantamine, i.e., 0.0165±0.0002 g/100 g. The limits of detection and quantification were 7.5 μg and 25 μg, respectively. Conclusion: Isolation of galantamine from S. fischeriana growing in Turkey is reported for the first time. An HPLC method was developed for identification and quantification of galantamine in Sternbergia species.
Authors and Affiliations
Özlem Bahadır ACIKARA, Betül Sever YILMAZ, Dilhun YAZGAN, Gülçin Saltan İŞCAN
Keywords
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- EP ID EP684695
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