Quantification of Genotoxic Alkylating Impurity Butyl3-Methyl-3-(6-methoxy-2-naphtyl) Glycidate at ppm Level by LCMS/MS in Naproxen Drug Substance
Journal Title: International Journal of Science and Research (IJSR) - Year 2013, Vol 2, Issue 12
Abstract
The objective of present research work is to develop a suitable LCMS/MS method for the quantitative determination of suspected genotoxic impurity namely Sec. Butyl 3-methyl-3-(6-methoxy-2-naphtyl) glycidate present in Naproxen drug substance at ppm level. The LCMS/MS method was developed on Luna C18, 50 mm column using the mobile phase consists a mixture of 10 mM Ammoinium acetate and Acetonirile with isocratic composition of 10:90 at a flow rate of 0.8 mL/min respectively. Ion source is electospray ionization (ESI) positive mode, source temperature is 350
Review of g*G-axioms in Topological Spaces
Review of g*G-axioms in Topological Spaces
Genetic Variability in Barley (Hordeum vulgare (L.)) Landrace Collections from Southern Ethiopia
Landraces are the major genetic resources of cultivated barley in Ethiopia. Two hundred seven accession and 18 released varieties were laid out in 15by15 simple lattice design and were planted in 2008 main cropping seaso...
Application of Laplace Transform to Newtonian Fluid Problems
Laplace transform is employed to solve the following three problems of Newtonian fluid flow on an infinite plate: (i) Stokes
School Leadership: Integrated School Leadership Practices in Secondary Schools of Harari Regional State
"Abstract: The main purpose of this study is to assess the integrated leadership practices of school principals in Harari Regional State secondary schools. The study employed a mixed research design by using both qualita...
Outcome Measurement of Electrical Stimulation on Quadriceps Muscles for Knee Osteoarthritis
"Introduction: Outcome measurement is very essential part to assess efficacy of treatment intervention.The first objective was to perform a review of all outcome measurement used in manangement of knee OA. Secondly to k...