Quantitative analysis of p53 substitution mutation and breast cancer; An informative study in Iranian population
Journal Title: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation - Year 2021, Vol 1, Issue 1
Abstract
Genetic factors, including genetic variations of important genes, may influence breast cancer susceptibility. One of important gene variations is p53 codon 72, which could impact the risk of breast cancer. There are three case-control genetic association studies regarding the relation of this polymorphism with the risk of breast cancer in Iranian females, but the outcomes are indecisive. Thus, a meta-analysis was made on Iranian population in this regard. The eligible studies were found using the search in appropriate databases. Extracted information from comprised studies was examined by the Open Meta analyst program. The analyzed data displayed that there is no substantial correlation among p53 codon 72 substitution with risk of breast cancer in CC vs. GG (OR= 0.844, 95%CI= 0.244-2.916, p= 0.789) and GC vs. GG (OR=1.215, 95%CI= 0.880-1.676, p= 0.237) models in Iran. Regarding the obtained outcomes, the aforementioned polymorphism is not considered as a molecular risk factor for breast cancer in Irsanian population.
Authors and Affiliations
Mojtaba Sabernezhad
Keywords
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- EP ID EP714119
- DOI 10.22034/CAJMPSI.2021.01.02
- Views 83
- Downloads 0
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