Quantitative analysis of p53 substitution mutation and breast cancer; An informative study in Iranian population
Journal Title: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation - Year 2021, Vol 1, Issue 1
Abstract
Genetic factors, including genetic variations of important genes, may influence breast cancer susceptibility. One of important gene variations is p53 codon 72, which could impact the risk of breast cancer. There are three case-control genetic association studies regarding the relation of this polymorphism with the risk of breast cancer in Iranian females, but the outcomes are indecisive. Thus, a meta-analysis was made on Iranian population in this regard. The eligible studies were found using the search in appropriate databases. Extracted information from comprised studies was examined by the Open Meta analyst program. The analyzed data displayed that there is no substantial correlation among p53 codon 72 substitution with risk of breast cancer in CC vs. GG (OR= 0.844, 95%CI= 0.244-2.916, p= 0.789) and GC vs. GG (OR=1.215, 95%CI= 0.880-1.676, p= 0.237) models in Iran. Regarding the obtained outcomes, the aforementioned polymorphism is not considered as a molecular risk factor for breast cancer in Irsanian population.
Authors and Affiliations
Mojtaba Sabernezhad
Keywords
Related Articles
- EP ID EP714119
- DOI 10.22034/CAJMPSI.2021.01.02
- Views 88
- Downloads 0
The moisture determination of bee pollen from Sivas Province in Anatolia and their antiproliferative activities in MCF-7 cell line
Pollen, one of the bee products, is an important nutrient for bees. Pollen is mainly used for feeding adult, old and larval bees to meet their needs for protein, vitamins and minerals. Since the protein content of pollen...
An in-depth study of specific pathway associated to abnormal reproductive system: A meta-analysis in a specific Caucasian ethnicity
Human methylenetetrahydrofolate reductase (MTHFR) gene plays a vital role in folate metabolism. This gene is located on chromosome 1 and has 12 exons. Many single nucleotide polymorphisms are found in MTHFR gene, in whic...
Structure and function of mitochondria and its role in male infertility
Infertility refers to the inability to conceive after at least 12 months of intercourse without prevention. About half of all infertility factors are due to male factors. Genetic factors are the important factors that co...
Infections of vector flow and palindrome catheters in permanent hemodialysis patients; epidemiology, surveillance, and evaluation during a 12-month period
Today, according to the high levels of chronic renal failure prevalence, the application of permanent catheters has been increased. Effective development and identification of influential factors can lead to the long-ter...
Correlation of a well-known genetic variation in one carbon metabolism pathway with breast cancer susceptibility in Iranian population
The one carbon metabolism pathway is an important cycle in the cellular reactions. One of a key gene in the mentioned pathway is methylenetetrahydrofolate reductase. This gene contains numerous variations that the rs1801...