Quantitative and Qualitative Composition of Colonic Content Microbiota in Diabetes Mellitus Type 1 Patients with Concomitant Chronic Purulent Maxillary Sinusitis
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 2, Issue 66
Abstract
There was performed a quantitative and qualitative assay of colonic content microbiota in 50 patients with diabetes mellitus (DM) type 1 and 47 patients with chronic purulent maxillary sinusitis and DM type 1 aged from 18 to 44 years old. The obtained data confirms that anaerobiotic bacteroides and aerobiotic coliform bacterium prevail in patients with chronic purulent maxillary sinusitis and DM type 1. by population level, quantitative majority coefficient and coefficient of importance there was determined a significant deficit of autochthon obligate Bifidobacterium and Lactobacillus in 41.3 and 51.3 %, respectively, by representation in human colonic biotic community and multiple role in microecological homeostasis support. Under the significant deficit of obligate physiologically useful for colonic biotic community Bifidobacteriums and Lactobacteriums there is determined the population increase of the level of bacteroides — 18.8 %, peptococcus — 64.9 %, clostridium — 88.0 %, coliform bacterium — 28.7 %, Proteus — 57 %, staphylococcus — 71.1 %, yeast-like fungiCandida — 92.0 %. Pathogenic (E.coli Hly+ and enteropathogenis strains) and opportunistic pathogenic bacterium (Enterobacter, Citrobacter, Proteus) contaminating colonic cavity in patients with chronic purulent maxillary sinusitis and DM type 1 achieve a high population level, mostly due to diabetes mellitus type 1 promoting the impairment of main colonic microflora functions. The obtained results could be a basis for studying a clinical course and optimization of treatment of inflammatory diseases of ear, nose, throat, including chronic purulent and purulent polypous sinusitis in patients with DM type 1 using lacto- and bifidobacteriums.
Authors and Affiliations
O. A. Mazur, N. V. Pashkovskaia, S. A. Levitskaia, A. G. Plaksivyi, I. V. Kalutskyi, K. I. Yakovets, O. D. Sapunkov
Keywords
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