Quantitative EEG Analysis in Patients With Severe Copd: Some Clues of Chronic Hypoxemic Degeneration

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Quantitative EEG Analysis in Patients With Severe Copd: Some Clues of Chronic Hypoxemic Degeneration

Journal Title: Journal of Neurological Sciences-Turkish - Year 2006, Vol 23, Issue 1

Abstract

Objective: This cross-sectional clinical and electrophysiological study was performed in order to determine the electroencephalographic correlates of cognitive disturbances in patients with severe chronic obstructive pulmonary disease (COPD), using quantitative electroencephalographic (QEEG) measurements. Materials and Methods: Electroencephalograms were obtained from 33 patients with severe or very severe COPD and from 20 age and sex matched controls. Results: Patients showed mild cognitive impairment unrelated to depression, especially in the construction, language and memory areas. Electroencephalograms revealed fronto-temporal slow waves especially in the left hemispheres. QEEG revealed higher frequency slow wave-bands and lower frequency beta activity, predominantly in the bilateral fronto-temporal localizations, in addition to decreased global relative beta power in patients with COPD. Analysis of variance of QEEG parameters and clinical characteristics showed that age, PaO2, PaCO2 and FEV1 had significant correlation with QEEG variables in different cerebral localizations. Conclusion: It was concluded that cognitive impairment in COPD patients was far from being a coincidence and some important clues about its degenerative basis, especially in data processing areas, existed.

Authors and Affiliations

Cengiz OZGE, Aynur OZGE, Ulku COMELEKOGLU, Ozgur UNAL

Keywords

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EP ID EP154773
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