Quinine Induced Headache and Visual Disturbances: A Case Report
Journal Title: Scholars Journal of Medical Case Reports - Year 2014, Vol 2, Issue 1
Abstract
Quinine is the chief alkaloid of cinchona, the powdered bark of the South American cinchona tree.Resistance to quinine is uncommon but increasing. It acts primarily against asexual erythrocytic forms and associated with dose-related toxicitieslike cinchonism, hypoglycemia, and hypotension. Mild forms of cinchonism consisting of high-tone deafness, visual disturbances and headache occur very frequently.Disturbance of vision had reported that in 17% of patients with quinine overdose, 75% of these patients were completely blind.A 30 years old female, admitted in the female general medicine department with the complaints of vomitings along with fever, chills, rigors and treated with a loading dose of quinine IV in normal saline, along with intravenously pantoprazole and intravenously ondansetron. Within one hour after administration of quinine intravenously, the patient complained severe headache and visual disturbances. Naranjo ADR scale was used to assess the causality of reported ADR (Score-7 indicating a probable association).Upon confirmation of the causality, quinine was withdrawn from the patient.The patient was treated for malaria with artesunate, ceftriaxone and was discharged two days later after he was found to be stable. Keywords: Adverse drug reaction; Cinchonism; headache; Naranjo ADR scale; Quinine; visual disturbances
Authors and Affiliations
Reddenna L, Venu Gopal D, Rama Krishna t, Ayub Basha S, Parveen S, Sree Nagavalli K
Keywords
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