Radiation-Induced Parotid Mucoepidermoid Carcinoma: A Systematic Review
Journal Title: Otolaryngology – Open Journal - Year 2017, Vol 3, Issue 1
Abstract
Background: Mucoepidermoid Carcinoma (MEC) of the parotid gland has been reported in patients who have been previously exposed to radiation. The purpose of this article is to review the literature examining radiation-induced parotid gland MEC. Procedure: A PubMed search of related articles in English was performed using a combination of the following keywords: “radiation induced parotid tumors,” “radiation induced salivary gland tumors,” “radiation induced parotid MEC,” “radiation induced salivary gland MEC,”. Results: The search results indicated 18 related articles describing the condition of 40 patients who have been previously exposed to radiation and subsequently developed parotid MEC. According to pre-existing studies, acute lymphoblastic leukemia (ALL) was a common observation among the patients following the initial diagnosis. The patients were divided into two groups on the basis of the treatment they received which included patients subjected to radiotherapy (RT) alone (n=13) and patients subjected to both radiotherapy and chemotherapy (n=27). The recorded latent time for secondary MEC development was significantly reduced in the chemoradiotherapy group of patients relative to the group undergoing radiotherapy alone. The overall survival rate for patients recorded over a period of 2 and 5 years was recorded as 97.4% and 95.4% respectively. The overall locoregional control rates recorded over a period of 2 years and 5 years were 97.4% and 93.1% respectively. There was no Significant difference in the recorded survival or locoregional control rates between the groups of patients exposed to radiation alone or a combination of chemotherapy and radiotherapy. Conclusion: Radiation-induced parotid MEC has an excellent prognosis supporting the survival of over 90% diagnosed patients.
Authors and Affiliations
Omar Ramadan
Keywords
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- EP ID EP546179
- DOI 10.17140/OTLOJ- 3-134
- Views 120
- Downloads 0
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