Radiation-induced Testicular Injury and Its Amelioration by Telfairia occidentalis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 12
Abstract
Aims: The radioprotective effect of Telfairia occidentalis aqueous extract (TOE) against gamma irradiation induced oxidative damage and altered sperm parameters in rats. Study Design: Randomized controlled experiment Place and Duration of Study: Experimental Animal Unit and Department of Anatomy, University of Ibadan between January and April, 2012. Methodology: Male Wistar strain rats were divided into six groups and pretreated with TOE (400, 800 and 1600 mg/kg of b.wt.) and vitamin E (VE) 50 mg/kg of b.wt prior to whole body gamma irradiation exposure of 2Gy. Sections of the testes were taken for the assessments of biochemical markers of oxidative stress: Lipid peroxidation (LPO), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) and histopathological variations. Results: Exposure of animals to 2Gy gamma radiation resulted in decreased sperm characteristics and increased sperm morphological abnormalities; significant elevation in lipid peroxidation (LPO) and hydrogen peroxides, and decreased activities of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GSH-Px) and levels of reduced glutathione (GSH) in testes; distorted architecture of seminiferous tubules from day 1 to 30 post-irradiation. The rats pretreated with TOE showed normal sperm parameters, normal testicular histo-architecture and normal antioxidant enzymatic activities. Conclusion: Aqueous extract of Telfairia occidentalis has radioprotective activities.
Authors and Affiliations
S. A. Adejuwon, J. O. Omirinde, A. P. Ebokaiwe, O. O. Aina, A. Adenipekun, E. O. Farombi
Keywords
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- EP ID EP348945
- DOI 10.9734/BJMMR/2014/8235
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