Radionuclide Methods for Pain Palliation
Journal Title: Nuclear Medicine Seminars - Year 2020, Vol 6, Issue 1
Abstract
Bone is a common metastatic site of cancer. Bone metastasis reduces life expectancy and results in serious symptoms and complications such as bone pain, pathological fractures, spinal cord compression, and malignant hypercalcemia. Therefore, appropriate approach to bone metastases is important. Radionuclide therapy is characterized by the reasonably selective delivery of therapeutic doses of radiation systemically to target tissues, with generally limited toxicity and few long-term side effects. Radionuclide therapy using bone-specific radiopharmaceuticals is a safe and effective therapy for bone pain palliation in metastatic bone disease, mainly prostate cancer. Although the additive value of β-emitting radionuclides on survival is debatable, the combination of radionuclide therapy with other therapies such as chemotherapy or external radiation therapy may improve patient survival. 223-Ra, which is an alpha-emitting agent, is a radiopharmaceutical with proven efficacy in pain palliation and survival in metastatic prostate carcinoma.
Authors and Affiliations
Mine Araz, Pınar Akkuş
Keywords
Related Articles
- EP ID EP685346
- DOI 10.4274/nts.galenos.2020.005
- Views 169
- Downloads 0
The Expectations of Pediatric Urologists from Nuclear Medicine
Nuclear medicine is frequently used by pediatric urologists. Treatment planning of ureterovesical junction obstruction, vesicoureteral reflux, and similar common congenital anomalies can only be done with well-reported n...
Renal Toxicity After Radionuclide Therapy
With the introduction of radionuclide therapies, the probability of toxicity has increased in critical organs such as kidney and bone marrow. Although these toxicity rates are relatively low in targeted therapies such as...
Guidelines for Myocardial Viability Imaging with F-18 FDG
Myocardial viability imaging with Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT), in patients who are appropriate for coronary revascularization, in the presence of le...
Differentiated Thyroid Carcinoma in Pediatric Age Group/Differences in Diagnosis, Therapy and Follow-up
Differentiated thyroid cancer in childhood is rare. Although its clinical course is quite aggressive with higher rates of lymph node and pulmonary metastases as compared to adults, the final outcome tends to be favorable...
Myocardial Perfusion SPECT Procedure Guideline
After Turkish Society of Nuclear Medicine “Cardiology Group” had first published “Nuclear Cardiology Practice Guidelines” in 2001, in line particular with the technological developments, significant changes both in the h...